刺五加注射液治疗急性脑梗塞的临床与实验研究

目的：观察刺五加注射液对急性脑梗塞的治疗效果并探讨其作用机理。方法：临床采用单盲对照法，刺五加组（３４例）用刺五加注射液６０－８０ｍｌ加入０．９％生理盐水５００ｍｌ中静注滴注，每天１次，共１４天；对照组（２６例）以低分子右旋糠酐５００ｍｌ静脉滴注，每天１次，共１４天，观察临床疗效。实验研究结扎双侧颈总动脉造成家兔急性不完全性脑缺血模型，刺五加组股静脉缓缓注射刺五加注射液１０ｍｌ每天１次，共７天。地

Clinical and Experimental Study on Treatment of Acute Cerebral Infarction with Acanthopanax Injection

OBJECTIVE: To evaluate the effect of Radix Acanthopanacis Senticosi in treating acute cerebral infarction and its mechanism. METHODS: Clinical study using single-blind, control trial, in which 60-80 ml of Acanthopanax Injection (AI) added to 500 ml of 0.9% normal saline was given by intravenous drip once a day for 14 days in the AI group(34 patients), while 500 ml of dextra-40 was given by the same way in the control group(26 patients). In experimental study, rabbit model of acute incomplete cerebral ischemia was made by ligation of bilateral common carotid artery. 10 ml of AI were given once daily intravenously for 7 days to the AI group and 10 ml of normal saline was given to the control group in the same way. Clinical effects (in clinical study) and effect of AI on cerebral oxygen free radicals (OFR), superoxide dismutase (SOD), and serum concentration of ACTH and cortisone were observed (in experimental study). RESULTS: Clinical study showed that the total effective rate of AI group (86%) was higher than that of the control group (50%) while nervous functional deficit score was lower in AI group (9.96 +/- 4.66) than that in the control group (13.56 +/- 1.84) significantly. Experimental study showed that the cerebral level of OFR decreased while SOD increased and serum concentration of ACTH and cortisone decreased after treatment in AI group. CONCLUSIONS: AI was effective in treating acute cerebral infarction, the mechanism is probably by ameliorating peroxidation in brain and improving hypothalamic-pituitary-adrenocortical axis function.