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肿瘤标志物CEA、CYFRA21-1联检在非小细胞肺癌中的诊断价值
引用本文:李红,万自芬. 肿瘤标志物CEA、CYFRA21-1联检在非小细胞肺癌中的诊断价值[J]. 放射免疫学杂志, 2006, 19(5): 432-433
作者姓名:李红  万自芬
作者单位:贵州省人民医院核医学科,550002;贵州省人民医院呼吸内科,550002
摘    要:目的:探讨血清肿瘤标志物癌胚抗原(CEA)和细胞角蛋白19片断抗原21-1(CYFRA21-1)联检在非小细胞肺癌中的诊断价值。方法:应用电化学发光法测定56例肺癌患者和45例肺良性病变(BLD)患者血清CEA和CYFRA21-1水平。结果:肺癌组CEA和CYFRA21-1水平明显高于肺良性病变组(P〈0.05)。CEA和CYFRA21-1在肺癌中的阳性率分别是55.35%(31/56)和64.28%(36/56)。两者联检对肺癌的敏感性为85.71%(48/56)。其中CEA在肺腺癌的敏感性为58.06%(18/31),CYFRA21-1对肺鳞癌的敏感性为68.00%(17/25)。结论:检测血清CEA和CYFRA21-1对非小细胞肺癌诊断有价值,联检CEA和CYFRA21-1可提高肺癌的诊断率。

关 键 词:非小细胞肺癌  癌胚抗原  细胞角蛋白19片断抗原21-1
收稿时间:2006-06-30
修稿时间:2006-06-30

Clinical Value of Combined Determination of Serum CEA and CYFRA21-1 Levels for Diagnosis of NSCLC
Li Hong,Wan Zifen. Clinical Value of Combined Determination of Serum CEA and CYFRA21-1 Levels for Diagnosis of NSCLC[J]. Journal of Radioimmanology, 2006, 19(5): 432-433
Authors:Li Hong  Wan Zifen
Abstract:Objective To explore the clinical value of combined determination of serum carcinoembryonic antigen(CEA) and cytokeration 19 fragment antigen(CYFRA21-1) levels for diagnosis of NSCLC.Methods The levels of CEA and CYFRA21-1 were measured with ECLIA in 56 patients with NSCLC and 45 patients with benign lung diseases(BLD).Results The serum levels of CEA and CYFRA21-1 in NSCLC patients were significantly higher than those in BLD patients(P<0.05).The positive rate of CEA and CYFRA21-1 in NSCLC patients were 55.35%(31/56) and 64.28%(36/56) respectively.The positive rate of combined detection in NSCLC patients was 85.71% (48/56).The positive rate of CEA in adenocarcinoma was 58.06%(18/31).The positive rate of CYFRA21-1 in squamous cell carcinoma was 68.00%(17/25).Conclusion Detection of serum levels of CEA and CYFRA21-1 were clinically useful for dragnosis of lung cancer,especially with combined determinations.
Keywords:none small cells lung cancer   CEA   CYFRA21 - 1
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