Independent predictors of neuronal adaptation in human primary visual cortex measured with high-gamma activity |
| |
Authors: | Matsuzaki Naoyuki Nagasawa Tetsuro Juhász Csaba Sood Sandeep Asano Eishi |
| |
Affiliation: | a Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit Medical Center, Detroit, Michigan 48201, USAb Department of Neurology, Children's Hospital of Michigan, Wayne State University, Detroit Medical Center, Detroit, Michigan 48201, USAc Department of Neurosurgery, Children's Hospital of Michigan, Wayne State University, Detroit Medical Center, Detroit, Michigan 48201, USA |
| |
Abstract: | Neuronal adaptation is defined as a reduced neural response to a repeated stimulus and can be demonstrated by reduced augmentation of event-related gamma activity. Several studies reported that variance in the degree of gamma augmentation could be explained by pre-stimulus low-frequency oscillations. Here, we measured the spatio-temporal characteristics of visually-driven amplitude modulations in human primary visual cortex using intracranial electrocorticography. We determined if inter-stimulus intervals or pre-stimulus oscillations independently predicted local neuronal adaptation measured with amplitude changes of high-gamma activity at 80-150 Hz. Participants were given repetitive photic stimuli with a flash duration of 20 μs in each block; the inter-stimulus interval was set constant within each block but different (0.2, 0.5, 1.0 or 2.0 s) across blocks. Stimuli elicited augmentation of high-gamma activity in the occipital cortex at about 30 to 90 ms, and high-gamma augmentation was most prominent in the medial occipital region. High-gamma augmentation was subsequently followed by lingering beta augmentation at 20-30 Hz and high-gamma attenuation. Neuronal adaptation was demonstrated as a gradual reduction of high-gamma augmentation over trials. Multivariate analysis demonstrated that a larger number of prior stimuli, shorter inter-stimulus interval, and pre-stimulus high-gamma attenuation independently predicted a reduced high-gamma augmentation in a given trial, while pre-stimulus beta amplitude or delta phase had no significant predictive value. Association between pre-stimulus high-gamma attenuation and a reduced neural response suggests that high-gamma attenuation represents a refractory period. The local effects of pre-stimulus beta augmentation and delta phase on neuronal adaptation may be modest in primary visual cortex. |
| |
Keywords: | Habituation Sensory gating Repetition suppression Event-related gamma-oscillations Pediatric epilepsy surgery |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|