| 中药茺蔚子中一个新C-28降三萜 |
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| 引用本文： | 郑玉清,闫合,韩婧,谭宁华. 中药茺蔚子中一个新C-28降三萜[J]. 中国中药杂志, 2012, 37(14): 2088-2091 |
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| 作者姓名： | 郑玉清 闫合 韩婧 谭宁华 |
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| 作者单位： | 1. 中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室,云南昆明650201;中国科学院研究生院,北京100049
2. 中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室,云南昆明,650201 |
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| 基金项目： | 国家自然科学基金项目(U1032602,91013002,30725048);国家自然科学基金-云南联合基金项目(U1032602);国家"重大新药创制"科技重大专项(2011ZX09307-002-02);国家重点基础研究发展计划(973)项目(2009CB522300) |
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| 摘 要： | 目的:研究益母草Leonurus japonicus果实茺蔚子中的化学成分。方法:茺蔚子乙酸乙酯部位经硅胶,RP-18,Sephadex LH-20和HPLC等色谱技术分离纯化,根据理化常数和波谱数据鉴定化合物的结构。结果:分离鉴定了2个具有特殊骨架的28位去甲基齐墩果烷型螺环三萜。结论:化合物1为新化合物,命名为茺蔚子三萜A(leonujaponin A),化合物2为已知化合物,鉴定为phlomistetraol B,均为首次从益母草属植物中分离得到。
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| 关 键 词： | 茺蔚子 C-28降三萜 茺蔚子三萜A |
| 收稿时间： | 2012-02-21 |
A new C-28 nortriterpenoid from fruits of Leonurus japonicus |
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| ZHENG Yuqing,YAN He,HAN Jing and TAN Ninghua. A new C-28 nortriterpenoid from fruits of Leonurus japonicus[J]. China Journal of Chinese Materia Medica, 2012, 37(14): 2088-2091 |
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| Authors: | ZHENG Yuqing YAN He HAN Jing TAN Ninghua |
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| Affiliation: | State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;Graduate University of Chinese Academy of Sciences, Beijing 100049, China;State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;Graduate University of Chinese Academy of Sciences, Beijing 100049, China;State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;Graduate University of Chinese Academy of Sciences, Beijing 100049, China;State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China |
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| Abstract: | Objective: To study the chemical constituents from the fruits of Leonurus japonicus.Method: The compounds were extracted by 70% methanol,then isolated and purified by column chromatography on silica gel,RP-18,Sephedax LH-20 and HPLC.Their structures were determined on the basis of spectroscopic data and physicochemical property.Result: Two 28-noroleanane-derived spirocyclic triterpenoids including a new acylated nortriterpenoid were isolated and identified as(17R)-19(18→17)-abeo-2α,18β,23-trihydroxy-3β-E-feruloyoxy-28-norolean-12-ene(1) and phlomistetraol B(2).Conclusion: Compound 1 is a new compound,named as leonujaponin A.Both compounds 1-2 are isolated for the first time from Leonurus plants. |
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| Keywords: | Leonurus japonicus C-28 nortriterpenoid leonujaponin A |
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