| 一种新型阿魏酸NO供体的合成 |
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| 引用本文： | 刘浩然,李燕来,张会杰,刘映,刘英姿.一种新型阿魏酸NO供体的合成[J].湖南师范大学学报(医学版),2011,8(2):92-94. |
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| 作者姓名： | 刘浩然 李燕来 张会杰 刘映 刘英姿 |
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| 作者单位： | 1. 湖南大学化学化工学院,湖南长沙,410082
2. 湖南师范大学医学院,湖南长沙41006 |
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| 摘 要： | 目的:依据药理学相关理论,设计并合成一种新型阿魏酸NO供体衍生物.方法:以阿魏酸为原料,经过羧基的酯化,溴化物取代以及硝化反应,合成阿魏酸NO供体衍生物.结果:共得到两个目标产物,分别是4-硝酸酯丙氧基-3-甲氧基苯丙烯酸甲酯和4-硝酸酯丁氧基-3-甲氧基苯丙烯酸甲酯,结构经1H NMR和质谱进行了确证.结论:首次合成...
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| 关 键 词： | 阿魏酸 NO供体 合成 |
Synthesis of new ferulic acid derivatives coupled to NO donors |
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| Liu Haoran,Li Yanlai,Zhang Huijie,Liu Ying,Liu Yinzi.Synthesis of new ferulic acid derivatives coupled to NO donors[J].Journal of Hunan Normal University(Medical Science),2011,8(2):92-94. |
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| Authors: | Liu Haoran Li Yanlai Zhang Huijie Liu Ying Liu Yinzi |
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| Institution: | Liu Haoran1,Li Yanlai1,Zhang Huijie1,Liu Ying1,Liu Yinzi2(1.College of Chemistry and Chemical Engineering,Hunan University,Changsha 410082,China;2.Medical College,Hunan Normal University,Changsha 410013,China) |
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| Abstract: | Objective To design and synthesize new ferulic acid derivatives coupled to NO donors based on the related theory of pharmacology.Methods Derivatives coupled to NO donors was synthesized from ferulic acid by esterification,bromination and nitrification.Results Two target products were prepared.They are 4-nitratepropoxy-3-methoxycinnamic acid methyl and 4-nitratebutoxy-3-methoxycinnamic acid methyl,which structures were authenticated by 1HNMR and MS.Conclusion A serious of new ferulic acid derivatives coupled to NO donors were prepared for the first time. |
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| Keywords: | ferulic acid NO donors synthesize |
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