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| 抗菌药物使用量与肺炎克雷伯菌耐药的相关性 | |
| 引用本文： | 岑慧,李文,庞伟君,蔡伟明.抗菌药物使用量与肺炎克雷伯菌耐药的相关性[J].实用医学杂志,2009,25(1):4-6. |
| 作者姓名： | 岑慧 李文 庞伟君 蔡伟明 |
| 作者单位： | 1. 广东省深圳市龙岗区人民医院呼吸内科,518172 2. 广东省湛江市广东医学院附属医院呼吸内科,524001 3. 广东省湛江市广东医学院附属医院检验科,524001 4. 广东省湛江市广东医学院附属医院药学部,524001 |
| 摘 要： | 目的:探讨某院抗菌药物使用量与痰培养肺炎克雷伯菌耐药水平变化之间的关系。方法:计算2005-2007年某院18种抗菌药物平均每日每百张床位所消耗的用药频率(DDDs)及同期痰培养肺炎克雷伯菌的耐药率,并对抗菌药物用量与耐药率进行相关性分析。结果:痰培养肺炎克雷伯菌对头孢他啶、哌拉西林/他唑巴坦、头孢哌酮/舒巴坦的耐药率与丁胺卡那霉素用量呈正相关(r分别为0.97,0.78,0.82;均P<0.05);对氨苄西林、氨苄西林/棒酸、头孢唑啉、哌拉西林/他唑巴坦的耐药率与左旋氧氟沙星用量呈正相关(r分别为0.77,0.73,0.75,0.83;均P<0.05);对氨苄西林/棒酸、庆大霉素、妥布霉素、环丙沙星、左旋氧氟沙星的耐药率与头孢哌酮/舒巴坦用量呈正相关(r分别为0.90,0.92,0.88,0.93,0.79,0.81;均P<0.05);对氨苄西林的耐药率与青霉素、克林霉素、哌拉西林/他唑巴坦用量呈正相关(r分别为0.88,0.81,0.80;均P<0.05)。结论:痰培养肺炎克雷伯菌对抗菌药物耐药水平变化与抗菌药物使用量之间存在相关关系。应提倡合理应用抗菌药物,控制和减缓细菌耐药性的增长。 |
| 关 键 词： | 克雷伯菌 肺炎 痰 抗菌药 抗药性 细菌 |
| 收稿时间： | 2008-9-17 |
Correlation between antimicrobial consumption and the drug-resistant rates of klebsiella pneumoniae |
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| CEN Hui,LI Wen,PANG Wei-jun,CAI Wei-ming.Correlation between antimicrobial consumption and the drug-resistant rates of klebsiella pneumoniae[J].The Journal of Practical Medicine,2009,25(1):4-6. | |
| Authors: | CEN Hui LI Wen PANG Wei-jun CAI Wei-ming |
| Abstract: | Objective To investigate the relationship between the consumption of antibacterial agents and drug-resistant rates of klebsiella pneumoniae(KP) in sputum cultivation in a hospital.Methods The total antibacterial consumption expressed as defined daily doses(DDD) per day per 100 beds,and the drug-resistant rates of KP were calculated,and the correlation between them was analyzed.Results The drug-resistant rates of KP to ceftazidime,piperacillin tazobactam,and cefoperazone sulbactam were positively associated ... |
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