调强放疗联合周剂量顺铂治疗老年人食管癌临床疗效观察

目的：观察调强放疗联合周剂量顺铂治疗老年人食管癌的近期疗效和毒副反应。方法将60例局部晚期老年食管癌患者采用数字表法随机分为同步放化疗组（ CRT组）30例和单纯放疗组（ RT组）30例，两组均采用6MV－X射线调强放疗，放疗剂量：DT 60 Gy／30次／6周。 CRT组在放疗第2天开始给予顺铂20～25 mg／m^2，1次／周，共6次。结果 CRT组、RT组近期有效率分别为80．0％、63．3％，差异有统计学意义（χ^2＝5．934，P＜0．05）。不良反应主要为骨髓抑制、放射性食管炎，基本为Ⅰ～Ⅱ级，两组不良反应差异无统计学意义（P＞0．05）。结论调强放疗联合周剂量顺铂治疗老年人食管癌近期疗效显著，不良反应轻，患者耐受性好，值得临床推广。

Curative effect of IMRT dose cisplatin combined weeks clinical efficacy of treatment of elderly esophageal cancer

Objective To observe the near future curative effect and toxicity of the combination of weekly dose of cisplatin in the treatment of elderly patients with esophageal cancer intensity-modulated radiotherapy observa-tion.Methods 60 patients with locally advanced esophageal cancer patients aged by method randomly were divided into synchronous chemotherapy group（ CRT group） and 30 cases of radiotherapy alone group（ RT group） 30 cases,the two groups using 6MV-X ray intensity modulated radiotherapy,radiotherapy dose：DT 60 Gy/30/6 week.The CRT treated group was given cisplatin 20-25mg/m^2 in the radiotherapy of second day,1 times per week,a total of 6 times. Results Radiotherapy and chemotherapy, radiotherapy group recent effective rate were 80.0% and 63.3%, the difference was statistically significant（χ^2 =5.934,P〈0.05）,P＆amp;lt 0.05）.The main toxicity was myelosuppres-sion,radiation esophagitis,basically I and II,no statistically significant difference between the two groups（P〉0.05）. Conclusion Intensity modulated radiotherapy combined with weekly dose of cisplatin in the treatment of elderly patients with esophageal cancer significant short-term effect,less adverse reactions,patient tolerance is good,which is worth the clinical promotion.