血清心肌酶水平与精神分裂症患者病情相关性研究

目的：探讨精神分裂症患者血清心肌酶谱的变化及其临床意义。方法测定405例精神分裂症患者入院时血清心肌酶（ CK、CK－MB、LDH、α－HBDH）水平，于入院治疗4周后复查血清心肌酶水平，分析其与病情的关系，并与100例健康人（对照组）进行对照。结果精神分裂症阳性症状组患者治疗前血清CK、CK－MB、LDH、α－HBDH分别为（1286．52±714．38） U／L、（40．72±27．38） U／L、（143．06±33．24） U／L、（115．75±22．74）U／L，CK、CK－MB均高于对照组（t ＝10．35、9．29，均 P＜0．01）；治疗4周后 CK、CK－MB、LDH、α－HBDH分别为（98．13±38．75）U／L、（12．87±5．73）U／L、（125．43±25．74）U／L、（102．15±26．86）U／L，呈下降趋势，与对照组比较，差异均无统计学意义（均P＞0．05）。结论急性发作期精神分裂症患者血清心肌酶CK、CK－MB升高可能与病情有关。

Correlation of serum cardiac enzymes activities and schizophrenia

Objective To investigate the changes of serum myocardial enzyme in schizophrenia patients spectrum and its clinical significance.Methods 405 patients with schizophrenia hospitalized patients serum myocar-dial enzyme （CK,CK-MB,LDH,α-HBDH level,） on admission and 4 weeks after treatment the serum myocardial enzyme level,analyze its relationship with the disease, and 100 healthy people （ control group） were compared. Results the positive symptoms of schizophrenia patients before treatment,serum CK,CK-MB,LDH,α-HBDH were （1 286.52 ±714.38） U/L,（40.72 ±27.38） U/L,（143.06 ±33.24） U/L,（115.75 ±22.74） U/L,CK,CK-MB were higher than those in the control group （t=10.35,9.29,all P〈0.01）;after 4 weeks of treatment,CK,CK-MB, LDH,α-HBDH were （98.13 ±38.75）U/L,（12.87 ±5.73）U/L,（125.43 ±25.74）U/L,（102.15 ±26.86）U/L, compared with the control group,the differences were not statistically significant（all P〉0.05）.Conclusion Serum myocardial enzyme CK and CK-MB increased level was related with diseasein the patients with acute exacerbation of schizophrenia.