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| 乙醛脱氢酶基因型对2-乙氧基乙醇代谢影响的研究 | |
| 引用本文： | 王三虎,高星,坂井公. 乙醛脱氢酶基因型对2-乙氧基乙醇代谢影响的研究[J]. 中华劳动卫生职业病杂志, 2001, 19(6): 450-452 |
| 作者姓名： | 王三虎 高星 坂井公 |
| 作者单位： | 1. 北京市丰台区卫生防疫站劳动卫生科 2. 北京市预防医学研究所 3. 日本东京劳灾病院 |
| 摘 要： | 探讨乙醛脱氢酶（ALDH2）不同基因型代谢2－乙氧基乙醇（EE）的能力是否存在差异。方法 采用个体采样，毛细柱气相色谱分析技术及PCR检测方法，比较不同基因型个累计接触EE剂量与2－乙氧基乙酸（EAA）浓度对数值回归直线的回归系数。结果 ALDH2不同基因型个体累计接触EE剂量与EAA浓度对数值存在线性关系，A基因型回归系数大于B基因型。结论 ALDH2A基因型代谢EE能力强于B基因型。 |
| 关 键 词： | 2－乙氧基乙醇 2－乙氧基乙酸 乙醛脱氢酶 基因型 有机溶剂 |
| 修稿时间： | 2000-12-07 |
Effect of aldehyde dehvdrogenase(ALDH2 ) genotypes on the 2-ethoxyethanol metabolism |
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| WANG Sanhu ,GAO Xing,TADASHI Sakai. Fengtai Hygiene and Anti Epidemics Station,Beijing ,China. Effect of aldehyde dehvdrogenase(ALDH2 ) genotypes on the 2-ethoxyethanol metabolism[J]. Chinese journal of industrial hygiene and occupational diseases, 2001, 19(6): 450-452 | |
| Authors: | WANG Sanhu GAO Xing TADASHI Sakai. Fengtai Hygiene Anti Epidemics Station Beijing China |
| Affiliation: | WANG Sanhu *,GAO Xing,TADASHI Sakai. *Fengtai Hygiene and Anti Epidemics Station,Beijing 100071,China |
| Abstract: | Objectives To explore whether different ALDH 2 genotypes of workers exposed to 2 ethoxyethanol(EE) have different activities for EE metabolism. Methods Personal monitoring,gas chromatographic determination and PCR methods were conducted in this study.Regression coefficients of EE exposure vs. 2 ethoxyaceticacid(EAA) were compared between genotype A and genotype B workers. Results Linear regression was found between cumulative dose of EE and logarithmic of EAA concentration.The regression coefficient of workers with ALDH 2 A was higher than that of those with ALDH 2 B. Conclusions Workers with ALDH 2 A genotype had higher activity for EE metabolism compared with workers with genotype B. |
| Keywords: | Ethoxyethanol 2 Ethoxyacetic acid Aldehyde dehydrogenase(ALDH 2) Genotype |
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