Protective response of Sestrin under stressful conditions in aging |
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| Affiliation: | 1. Department of Biotechnology, Mohanlal Sukhadia University, Udaipur, Rajasthan, 313001, India;2. Department of Biophysics, All India Institute of Medical Science, New Delhi, 110029, India;1. Department of Cell Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA, USA;2. Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA;1. Department of Pharmacy, Xianyang Hospital of Yan’an University, No. 38 Wenlin Road, Xianyang, 712000 Shaanxi Province, China;2. Yizhixin Biotechnology Institute, Xi’an, 710003 Shaanxi Province, China;1. Dino Ferrari Centre, Neuroscience Section, Department of Pathophysiology and Transplantation (DEPT), University of Milan, Via Francesco Sforza 35, 20122 Milan, Italy;2. Neurology Unit, IRCCS Foundation Ca’ Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy;1. Department of Life Sciences, University of Coimbra, Calçada Martim de Freitas, 3000-456, Coimbra, Portugal;2. CNC - Center for Neuroscience and Cell Biology, CIBB, 3004-504, Coimbra, Portugal;1. Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, Sichuan, China;2. Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, Sichuan, China |
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| Abstract: | The aging at cellular level manifests itself in the form of uncontrolled formation of ROS, chronic inflammation, and increased susceptibility to cellular stress. Aging is often regarded as a risk factor for several diseases due to several age-associated pathological changes in cells. Sestrin (Sesn) is an important molecule for controlling normal cellular physiology and play a significant role in the progression of certain age-associated cellular pathologies. This review deals with the structure, function, regulation, signaling network, and the potential role of Sesn in age-associated cellular pathophysiology. The cellular response mediated by Sesn under stressful conditions and rescue mechanism is discussed. It would be interesting to find out the precise physiological role of Sesn in the regulation of cellular aging. The anti-aging activity of Sesn may benefit to prevent various age-associated diseases and have clinical utility in diagnostic and therapeutic intervention. |
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| Keywords: | Aging cellular pathology Sestrin Oxidative stress Nutrient starvation Dysregulated autophagy |
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