TC与NP方案治疗晚期非小细胞肺癌的疗效对比观察

目的 比较紫杉醇（PTX）加卡铂（CBP）（TC方案）与长春瑞滨（NVB）加顺铂（DDP）（NP方案）治疗晚期非小细胞肺癌（NsCLC）的疗效和不良反应。方法 56例初治晚期NSCLC依照患者就诊化疗的先后顺序随机分入TC组和NP组，化疗2周期后进行评价。结果 TC组完全缓解率为10．7％，部分缓解率为42．9％，总有效率为53．6％，NP组完全缓解率为7．1％，部分缓解率为42．9％，总有效率为50．0％，2组疗效无显著性差异（P〉0．05）。TC组胃肠道反应、肾毒性和肌肉关节疼痛发生率均比NP组低，有显著性差异（P〈0．05）。结论 TC方案和NP方案均可作为治疗晚期NSCLC的一线化疗方案。

Comparison of Therapeutic Effect of Paclitaxel Plus Carbplatin and Vinorelbine Plus Cisplatn in Advanced No Small Cell Lung Cancer

Objective To compare the therapeutic effect and toxicity of paclitaxel plus carboplatin and vinorelbine plus cisplatin in advanced non-small cell lung cancer(NSCLC).Methods 56 untreated patients with advanced NSCLC were randomly divided into group TC and group NP.Therapeutic effect and toxicities were assessed after 2 cycles of chemotherapy.Results The overall response rate(RR) was 53.6% in TC group and 50.0% in NP group,showing no significant difference between the two groups(P>0.05).Gastrointestinal reaction,myalgia or orthralgia and renal dysfunction were lower in group TC than in group NP(P<0.05).Conclusion Both TC and NP regimen may be used as first-line chemotherapy in patients with NSCLC.