改良PUVA疗法治疗慢性斑块性银屑病疗效分析

目的：探索用改良PUVA疗法治疗慢性斑块性银屑病的疗效和安全性。方法：67例寻常型银屑病患者口服8-MOP0．6mg/kg后照射UVA和UVB，每周3次，共治疗8周，用PASI积分评价疗效，并记录不良反应。结果：治疗开始2-4周后出现疗效，随着治疗时间的延长，PASI总积分逐渐下降，有效率逐渐提高，在治疗结束时痊愈率达到96．5％，有效率达100％。27例患者(40．3％)出现不良反应，绝大多数为轻度，没有因不良反应停止治疗的病例。结论：改良PUVA疗法治疗慢性斑块性银屑病具有良好疗效和安全性。

Treatment of chronic plaque - type psoriasis with modified PUVA therapy

Objective: To assess the efficacy and safety of modified PUVA therapy in the treatment of chronic plaque-type psoriasis. Methods: Sixty-seven patients were treated with a modified PUVA regimen, 3 times a week for 8 weeks. On each treatment, the patients took 8-methoxypsoralene (8-MOP) at dose of 0.6mg/kg, and then, UVA and UVB radiation were followed 2 hours after the oral medication. The efficacy was assessed by change in PASI score and the adverse events were recorded. Results: The efficacy appeared after the treatment in 2 to 4 weeks and the lesions were improved with time. At the end point, all patients showed marked improvement with a cure rate of 96.5%. Twenty-seven patients (40.3%) experienced systemic or local adverse reactions, most of which were mild. Conclusion: The current study demonstrates that the modified PUVA therapy is effective and safe in the treatment of chronic plaque-type psoriasis.