Inflammation in diabetic retinopathy |
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| Authors: | Tang Johnny Kern Timothy S |
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| Affiliation: | aDepartment of Ophthalmology and Visual Sciences, University Hospitals Eye Institute, Case Western Reserve University, Cleveland, OH, USA;bDepartment of Medicine, Case Western Reserve University, 434 Biomedical Research Building, Euclid Ave, Cleveland, OH 10900, USA;cResearch Service, Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA |
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| Abstract: | Diabetes causes a number of metabolic and physiologic abnormalities in the retina, but which of these abnormalities contribute to recognized features of diabetic retinopathy (DR) is less clear. Many of the molecular and physiologic abnormalities that have been found to develop in the retina in diabetes are consistent with inflammation. Moreover, a number of anti-inflammatory therapies have been found to significantly inhibit development of different aspects of DR in animal models. Herein, we review the inflammatory mediators and their relationship to early and late DR, and discuss the potential of anti-inflammatory approaches to inhibit development of different stages of the retinopathy. We focus primarily on information derived from in vivo studies, supplementing with information from in vitro studies were important. |
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| Keywords: | Diabetic retinopathy Inflammation Diabetes Pathogenesis |
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