Risk assessment to guide the prevention of cervical cancer |
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Authors: | Castle Philip E Sideri Mario Jeronimo Jose Solomon Diane Schiffman Mark |
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Institution: | a Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD b Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD c Preventive Gynecology Unit, European Institute of Oncology, Milan, Italy. |
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Abstract: | Advances in screening and diagnosis make it increasingly possible to prevent cervical cancer. However, if misused or poorly understood, these new tools will only increase costs and potentially harm patients without benefit. As a framework for standardized care that maximizes patient safety and well-being, we propose that a risk model be adopted to guide clinical management now and in the future. The model would use thresholds of increasing risk for cervical precancer and treatable cancer to guide clinical decision making for screening intensity, diagnostic evaluation, or treatment. Experts would decide on these risk thresholds and stratum based on the patient risk to benefit, independent of current (eg, cytology, carcinogenic HPV testing, and colposcopy) and future methods of measuring risk. A risk management model for cervical cancer prevention, based on appropriate clinical actions that correspond to risk stratum, can result in better allocation of resources to and increased safety for women at the greatest risk and increased well-being for women at the lowest risk. |
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Keywords: | biopsy carcinogenic human papillomavirus cervical cancer cervical cytology cervical precancer colposcopy human papillomavirus vaccination loop electrosurgical excision procedure Papanicolaou smears risk |
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