全脑放疗同步VM26+DDP化疗治疗肺癌脑转移

目的:评价全脑放疗同步VM26 DDP化疗治疗肺癌脑转移的近期疗效和毒性。方法:全脑照射剂量30Gy,每次3 Gy,5次/周,或40 Gy,每次2 Gy,5次/周。化疗DDP20 mg/m2,静脉滴注,连续4 d;VM26 60 mg/m2,静脉滴注,连续3 d,3~4周为1周期。全脑放疗5次后开始同步化疗。放疗结束并完成2周期化疗后复查头部CT或MRI评价疗效。结果:全组38例肺癌脑转移患者均完成全脑放疗及2周期化疗。脑转移灶有效率68.4%,CR11例(28.9%),PR15例(39.5%)。结论:全脑放疗同步VM26 DDP化疗治疗肺癌脑转移疗效较好,毒副反应不大,患者可耐受。

Concomitant Whole Brain Radiotherapy and VM26+DDP Chemotherapy in Brain Metastasis of Lung Cancer

Objective:To evaluate the efficacy and toxicity of concomitant chemoradiotherapy in patients with brain metastasis from lung cancer.Methods:Thirty-eight patients suffering from lung cancer with brain metastasis were included in this study.Treatment consisted of concomitant whole brain radiotherapy(WBRT) with a dose of 30 Gy in 10 fractions or 40 Gy in 20 fractions.Concomitant chemotherapy of VM26 DDP regimen with teniposid 60 mg/m~2 on d1 to d3,cisplatin 20 mg/m~2 on d1 to d4,repeating every 3 or 4 weeks.The response was evaluated by CT or MRI after WBRT and 2 cycles of chemotherapy was completed.Results:ALL patients completed WBRT and concomitant chemotherapy.The response rate of brain disease was 68.4% with CR for 11 patients(28.9%) and PR for 15(39.5%).Conclusion:Concomitant WBRT and VM26 DDP chemotherapy can be performed for the patients with brain metastasis from lung cancer with a remarkable response rate.