自拟抗弓形虫汤对急性弓形虫感染小鼠SOD、MDA的影响

目的:探讨自拟抗弓形虫汤对急性弓形虫感染小鼠血浆、心、肝、肺超氧化物歧化酶(SOD)和丙二醛(MDA)含量的影响。方法:昆明小鼠80只,随机分为抗弓形虫汤组(灌胃自拟抗弓形虫汤)、复方SMZ组(灌胃复方SMZ)、模型组和正常组,每组20只。用RH株弓形虫建立小鼠模型,观察小鼠发病及存活时间,血浆、心、肝、肺SOD活性和MDA含量。结果:自拟抗弓形虫汤能推迟弓形虫感染小鼠的发病时间,延长弓形虫感染小鼠的生存时间;可明显提高小鼠SOD活性,同时降低MDA含量。与复方SMZ组比较,差异有显著性(P<0.05)。结论:自拟抗弓形汤能改善弓形虫感染小鼠的存活质量,并具有抗氧化损伤作用。

The Effect of Kanggongxingchong decoction on SOD and MDA in Mice Infected with Toxoplsma Gondii

Objective:To investigate the effect of Kanggongxingchong decoction(KGXCT)on SOD and MDA in mice infected with Toxoplasma gondii.Methods:Eighty Mice were divided into KGXCT group(intragastric administration KGXCT),Compound SMZ group(intragastric administration compound SMZ),Model group,Normal group.The mice model was made by RH toxoplsma gondii,SOD activities and the content of MDA in mice serum,heart,liver and lung were detected.Rusults:KGXCT group can delay the invasion time of mice infected by toxoplsma gondii,and their life were extend.When it came to the comparison of the activity of SOD and the content of MDA in each group of mice's serum,heart,liver and lung,the Normal group and model group had remarkable difference(P<0.05).Conclusion:KGXCT can increase greatly the quality of life,and can anti-oxidation injury in mice infected with Toxoplasma gondii.