| 分枝杆菌多糖的长期毒性实验研究 |
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| 引用本文： | 吴萍,赵文明.分枝杆菌多糖的长期毒性实验研究[J].首都医学院学报,1998,19(1):13-18. |
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| 作者姓名： | 吴萍 赵文明 |
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| 作者单位： | 首都医科大学劳动卫生教研室，首都医科大学应用免疫研究室 |
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| 摘 要： | 对分枝杆菌多糖（ＭＰＳ）进行了长期毒性实验。结果：ＭＰＳ１．５、７．５、１５．０μｇ／ｋｇ体重３个剂量组与对照组大鼠在生长发育、食物利用系数、血液常规、生化指标、脏体比和脏器病理检查等方面均无统计学上的显著差异（Ｐ＞０．０５）。表明ＭＰＳ在实验剂量范围内对大鼠无不良影响，提示它在临床上长期使用是安全的。
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| 关 键 词： | 分枝杆菌多糖 免疫调节剂 长期毒性实验 |
| 收稿时间： | 1997-04-25 |
A Long-Term Toxicity Test of Mycobacterial Polysaccharides |
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| Wu Ping,Su Yilan,Chen Zhenliang,Liu Zhen,Zhang Jie,Li Juan,Jiang Zhicheng,Zhao Wenming,Chen Ren.A Long-Term Toxicity Test of Mycobacterial Polysaccharides[J].Journal of Capital University of Medical Sciences,1998,19(1):13-18. |
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| Authors: | Wu Ping Su Yilan Chen Zhenliang Liu Zhen Zhang Jie Li Juan Jiang Zhicheng Zhao Wenming Chen Ren |
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| Institution: | 1. Department of Industrial Health, Capital University of Medical Scienses;2. Department of Immunology, Capital University of Medical Sciences |
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| Abstract: | long term toxicity test of Mycobacterial polysaccharides(MPS)was carried out. Experimental groups with three different doses(1.5、7.5 and 15.0 μg/kg)of MPS were compared with the control in the parameters of growth ratio, coefficieny of food utilization, routine and specific tests of blood, OW/BW ratio and pathological examinations. Results showed no significant statistical differences between the experimental animals and controls. This study shows that MPS with such test doses has no adverse effect to the rats denoting that MPS can be used for long term treatment. |
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| Keywords: | Mycobacterial polysaccharide immunomodulator long term toxicity test |
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