参松养心胶囊对大鼠心肌缺血/再灌注后室性心律失常的影响

目的 在SD大鼠的心肌缺血/冉灌汴模型上探讨参松养心胶囊对缺血再灌注后室性心律失常的作用.方法 将30只SD大鼠随机分为对照组和用药组:参松养心胶囊(4 g·kg-1·d-1),连续灌胃2周后建立心肌缺血/再灌注模型.记录缺血始30 min内和再灌注60 min内室性心律失常发生的次数和持续时间.再灌注60 min后摘除心脏测算心肌梗死面积.结果 (1)缺血后室性心律失常:参松养心胶囊组大鼠心肌缺血后室性早搏的发作次数[(6.7±0.3)次/30 min比(15.0±1.1)次/30 min,P=0.007]、室速的发作次数[(3.5±0.2)次/30 min比(14.7±0.6)次/30 min,P=0.003]和发作持续时间[(10.3±2.0)s比(28.3±4.6)s,P=0.018]以及室颤的发作持续时间[(7.0±1.1)s比(15.0±1.7)s,P=0.031]比对照组均明显减少;(2)再灌注后室性心律失常:参松养心胶囊组大鼠再灌注后室性早搏的发作次数[(5.3±0.8)次/60 min比(15.6±1.8)次/60 min,P=0.002]以及再室速发作的持续时间[(4.6±0.5)s比(13.5±0.6)s,P:0.001]比对照组有显著降低.结论 参松养心胶囊可以明显减少大鼠心肌缺血后窜性心律失常的发生,而且对于降低再灌注后室性早搏的发作次数和室性心动过速的发生持续时间也有显著效果.

Effects of Shen-song-yang-xin capsule on ventricular arrhythmias in ischemia/reperfusion: experiment with rats

Objective To investigate the effects of Shen-song-yang-xin capsule containing ginseng, ophiopogon root, red sage root, etc, on the ventricular arrhythmias caused by ischemic/ reperfusion.Methods Thirty SD rats were randomly divided into 2 equal groups:Shen-song-yang-xin group undergoing occlusion for 30 minutes followed by reperfusion for 60 minutes, and control group undergoing ischemia/ reperfusion only.Electrocardiography was conducted to record the ventricular arrhythmias, and after 60 minutes of reperfusion the rats were killed with their hearts removed to measure the infarction size.Results (1) During the 30 minutes' ischemia, the average number of episode of ischemia-induced premature ventricular contraction of the Shen-song-yang-xin group was (6.7 ± 0.3) beats/30 min, significantly lower than that of the control group[(15.0 ± 1.1) beats/30 min,P =0.007];the average number of episode of ischemia-induced ventrieular taehycardia of the Shen-song-yang-xin group was (3.5 ± 0.2) episodes/30 min, significantly lower 5than that of the control group[(14.7 ± 0.6) episedes/30 min, P = 1.003];the duration of ventricular tachycardia of the Shen-song-yang-xin group was (10.13 ± 2.1) s, significantly shorter than that of the control group[(28.3±4.6) s,P =0.018];and the duration of ventricular fibrillation of the Shen-song-yang-xin group was (7.0 ± 1.1) s, significantly shorter than that of the control group[(15.0 ± 1.7) s,P =0.031].(2) 60 minutes after the reperfusion, the number of episode of premature ventricular contraction of the Shen-snng-yang-xin group was (5.3 ± 0.8) beats/60 min, significantly lower than that of the control group[(15.6 ± 1.8) beats/60 min, P = 0.002], and the duration of reperfusion-induced ventricular tachycardia was (4.6 ± 0.5) s, significantly shorter than that of the control group[(13.5 ± 0.6) s,P = 0.001].Conclusion Shen-song-yang-xin capsule significantly reduces the ischemia-induced ventricular arrhythmia, average episode number of reperfusion-induced premature ventricular contraction, and duration of reperfusion-induced ventricular taehycardia.