Imx 系统连续监测肝癌及慢性肝炎患者血清甲胎蛋白的变化

采用全自动免疫分析系统（Ｉｍｘ），对原发性肝癌（ＰＨＣ）、慢性活动性肝炎（ＣＡＨ）患者的血清甲胎蛋白（ＡＦＰ）含量进行观察。结果：ＰＨＣ患者血清ＡＦＰ含量的异常率为７５％（６６／８８），ＣＡＨ患者的异常率为２１．８％（２２／１０１）。并对１１例ＰＨＣ患者进行了手术前后ＡＦＰ含量的动态观察，对１５例ＣＡＨ患者进行了ＡＦＰ含量连续监测。发现：ＰＨＣ患者术后ＡＦＰ持续增高者预后不良；ＣＡＨ患者ＡＦＰ持续增高有癌变的可能。提示：ＡＦＰ含量的变化与ＰＨＣ和ＣＡＨ的病程变化和预后相吻合。

Measurement of Serum Alpha fetoprotein in Patients with Primary Hepatocellular Carcinoma and Chronic Active Hepatitis by Immunoassay System Imx

Using fully automated immunoassay system Imx, the serum alpha fetoprotein(AFP)levels in patients with primary hepatocellular carcinoma(PHC)and chronic active hepatitis(CAH)were quantitatively determined. Results: In 75% of patients with PHC, the serum AFP levels were unnormal. In 11 patients, before and after operation, the serum AFP levels were observed dynamically. The serum AFP levels were elevated in 21.8% of 110 patients with CAH. In 13 of 15 cases, the serum AFP levels were from 14.27 nmol/L to normal. In another 2 cases, the serum AFP levels were persistently high, denoting a poor prognoses. Changes in contents of AFP coincided with changes of disease course and prognosis of PHC and CAH.