急性冠状动脉综合征患者血栓前体蛋白的检测意义

目的 :探讨急性冠状动脉 (冠脉 )综合征患者血栓前体蛋白的检测意义。　　方法 :将 5 7例急性冠脉综合征患者分为急性心肌梗死组 (AMI组 ,n =2 6)和不稳定性心绞痛组 (UA组 ,n =3 1) ,分别测定症状发作 6h内及 2 4h时的血栓前体蛋白 (TPP)和心肌肌钙蛋白T (cTnT) ,并和 3 0例正常的健康体检者 (对照组 )做比较。　　结果 :症状发作 6h内 ,AMI组血栓前体蛋白显著高于UA组及对照组 (P <0 0 1) ,而心肌肌钙蛋白T无显著变化 ;症状发作 2 4h时 ,AMI组及UA组心肌肌钙蛋白T显著高于对照组 (P <0 0 1) ,AMI组心肌肌钙蛋白T显著高于UA组(P <0 0 1) ,而血栓前体蛋白无显著变化。　　结论 :血栓前体蛋白为AMI的早期诊断指标 ;在排除身体其他部位有血栓的情况下 ,血栓前体蛋白可以鉴别诊断AMI与UA ,但还有待更多的病例证实。

Value of Measuring Thrombus Precursor Protein in Patients With Acute Coronary Syndrome

Objective: To investigate the values of measuring thrombs precursor protein(T_PP) in patients with acute coronary syndrome. Methods: T_PP and cardiac troponin T(cTnT) were measured and compared in 57 patients with acute coronary syndrome and 30 healthy controls within 6 hours and at 24 hours after the onset of symptoms. Results: Significantly abnormal concentrations of T_PP were observed in patients with acute myocardial infarction(AMI) compared to patients with UA and the controls within 6 hours after the onset of symptoms(p<0.01), and the cTnT level was similar in all groups. cTnT was significantly higher in patients with AMI and UA than that in the controls at 24 hours after the onset of symptoms(p< 0.01). The concentration of cTnT was also elevated in patients with AMI compared to these with UA. The change of T_PP had no statistical value in all groups. Conclusion:T_PP can be used as a diagnostic parameter for early AMI. It remains to be studied whether T_PP can be used to differentiate AMI from UA when thrombus is excluded in other parts of the body.