| 热熔挤出技术制备吲哚美辛速释胶囊 |
| |
| 引用本文： | 王君君,赵会英,赵一鸣,丁雪佳. 热熔挤出技术制备吲哚美辛速释胶囊[J]. 中国药业, 2008, 17(15): 47-49 |
| |
| 作者姓名： | 王君君 赵会英 赵一鸣 丁雪佳 |
| |
| 作者单位： | 1. 北京化工大学生命科学与技术学院,北京,100029
2. 北京化工大学材料科学与工程学院,北京,100029 |
| |
| 摘 要： | 目的以热熔挤出技术制备吲哚美辛速释胶囊。方法选用不同的亲水性载体，如聚乙二醇（PEG-6000，PEG-10000）、聚乙烯吡咯烷酮（PVP—k30）、泊洛沙姆188（F-68），应用热熔挤出技术制备吲哚美辛速释胶囊，比较其与物理混合物胶囊及原料药胶囊的药物溶出速率。结果与相应的物理混合物胶囊及原料药胶囊相比，用热熔挤出技术制备的速释胶囊吲哚美辛的溶出速率快，且以PEG-10000／PVP—k30／F-68／吲哚美辛质量比：1：1：1：1系统的药物溶出速率最快。结论用热熔挤出技术制备的吲哚美辛速释胶囊可提高药物的溶出度。
|
| 关 键 词： | 热熔挤出技术 吲哚美辛 扭矩 聚乙二醇 聚乙烯吡咯烷酮 泊洛沙姆188 |
Indomethacin Immediate Release Capsules Produced by Hot-melt Extrusion |
| |
| Affiliation: | Wang Junjun, Zhao Huiying, Zhao Yiming, Ding Xueji (1. College of Life Science and Technology, Beifing University of Chemical Technology, Beifing, China 100029; 2. College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, China 100029) |
| |
| Abstract: | Objective To prepare Indomethacin immediate release capsules by means of hot-melt extrusion （HME） using indomethacin as the model drug. Methods Various hydrophilic excipients such as PEG-6000, PEG-10000, PVP-k30, F-68 were composed into the formulations to make indomethacin immediate release capsules. The dissolution rate was compared between indomethacin immediate release capsules and the physical mixture capsules and the raw material capsules. Results The HME technique enhanced the dissolution rate of indomethacin. The system of PEG-10000/PVP-k30/F-68/ indomethacin （1：1：1：1） showed the fastest dissoiution rate. Conclusion The HME technique can be used to enhance the drug dissolution rate. |
| |
| Keywords: | hot - melt extrusion indomethacin torque PEG PVP - k30 F - 68 |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
