| 氟伐他汀钠的合成 |
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| 引用本文： | 蔡正艳,宁奇,周伟澄. 氟伐他汀钠的合成[J]. 中国医药工业杂志, 2007, 38(2): 73-75 |
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| 作者姓名： | 蔡正艳 宁奇 周伟澄 |
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| 作者单位： | 上海医药工业研究院,上海,200437 |
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| 摘 要： | 氟苯和氯乙酰氯经付-克酰化、与N-异丙基苯胺缩合后环合，得3-（4-氟苯基）-1-异丙基-1H-吲哚，再经Vilsmeier-Haack反应、与乙酰乙酸甲酯缩合、选择性还原后水解成盐得HMG CoA还原酶抑制剂类降血脂药氟伐他汀钠，总收率约26％。
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| 关 键 词： | 氟伐他汀钠 HMG CoA还原酶抑制剂 降血脂药 合成 |
| 文章编号： | 1001-8255（2007）02-0073-03 |
| 修稿时间： | 2006-10-19 |
Synthesis of Fluvastatin Sodium |
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| CAI Zheng-yan,NING Qi,ZHOU Wei-cheng. Synthesis of Fluvastatin Sodium[J]. , 2007, 38(2): 73-75 |
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| Authors: | CAI Zheng-yan NING Qi ZHOU Wei-cheng |
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| Affiliation: | Shanghai Institute of Pharmaceutical Industry, Shanghai 200437 |
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| Abstract: | Fluvastatin sodium, an antihypercholesterolemic HMG CoA reductase inhibitor, was synthesized from fluorobenzene by Friedel-Crafts acylation with chloroacetyl chloride, followed by condensation with N-isopropyl aniline and cyclization to give 3-(4-fluorophenyl)-1-isopropyl-1H-indole, which was subjected to Vilsmeier-Haack reaction, condensation with methyl acetoacetate, selective reduction, hydrolysis and salt formation with an overall yield of 26%. |
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| Keywords: | fluvastatin sodium HMG CoA reductase inhibitor antihypercholesterolemic synthesis |
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