The HMGB1 signaling pathway activates the inflammatory response in Schwann cells |
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Authors: | Li-li Man Fan Liu Ying-jie Wang Hong-hua Song Hong-bo Xu Zi-wen Zhu Qing Zhang Yong-jun Wang |
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Institution: | 1.Key Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, China;2.Department of Oncology, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China;3.Department of Pediatrics, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China;4.Medical College, Nantong University, Nantong, Jiangsu Province, China |
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Abstract: | Schwann cells are not only myelinating cells, but also function as immune cells and express numerous innate pattern recognition receptors, including the Toll-like receptors. Injury to peripheral nerves activates an inflammatory response in Schwann cells. However, it is unclear whether specific endogenous damage-associated molecular pattern molecules are involved in the inflammatory response following nerve injury. In the present study, we demonstrate that a key damage-associated molecular pattern molecule, high mobility group box 1(HMGB1), is upregulated following rat sciatic nerve axotomy, and we show colocalization of the protein with Schwann cells. HMGB1 alone could not enhance expression of Toll-like receptors or the receptor for advanced glycation end products(RAGE), but was able to facilitate migration of Schwann cells. When Schwann cells were treated with HMGB1 together with lipopolysaccharide, the expression levels of Toll-like receptors and RAGE, as well as inflammatory cytokines were upregulated. Our novel findings demonstrate that the HMGB1 pathway activates the inflammatory response in Schwann cells following peripheral nerve injury. |
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Keywords: | nerve regeneration peripheral nerve injury sciatic nerve transection Schwann cells HMGB1 migration inflammatory response TLRs peripheral nerves DAMPs cytokines neural regeneration |
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