Hyperbaric oxygen therapy combined with Schwann cell transplantation promotes spinal cord injury recovery |
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| Authors: | Chuan-gang Peng Shu-quan Zhang Min-fei Wu Yang Lv Dan-kai Wu Qi Yang Rui Gu |
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| Institution: | 1.Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China;2.Department of Orthopedics, Tianjin Nankai Hospital, Tianjin, China;3.Department of Dynaecology and Obstetrics, China-Japan Union Hosptial of Jilin University, Changchun, Jilin Province, China |
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| Abstract: | Schwann cell transplantation and hyperbaric oxygen therapy each promote recovery from spinal cord injury, but it remains unclear whether their combination improves therapeutic results more than monotherapy. To investigate this, we used Schwann cell transplantation via the tail vein, hyperbaric oxygen therapy, or their combination, in rat models of spinal cord contusion injury. The combined treatment was more effective in improving hindlimb motor function than either treatment alone; injured spinal tissue showed a greater number of neurite-like structures in the injured spinal tissue, somatosensory and motor evoked potential latencies were notably shorter, and their amplitudes greater, after combination therapy than after monotherapy. These findings indicate that Schwann cell transplantation combined with hyperbaric oxygen therapy is more effective than either treatment alone in promoting the recovery of spinal cord in rats after injury. |
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| Keywords: | nerve regeneration spinal cord injury Schwann cells hyperbaric oxygen therapy rats spinal cord injury transplantation motor function repair central nervous system electrophysiology neural regeneration |
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