不稳定型心绞痛患者血管内超声下斑块性质与高敏C反应蛋白的关系

目的：探讨不稳定型心绞痛患者（UAP）98例在血管内超声（IVUS）下斑块性质与高敏C反应蛋白（hs-CRP）的关系。方法：在进行冠状动脉造影前24h检测血hs-CRP，冠状动脉造影后对靶病变进行IVUS。分析UAPIVUS下斑块性质与hs-CRP的相关性。结果：hs-CRP升高组（44例）有软斑块者36．7％、斑块破裂者15．3％、血栓形成者11．2％均较hs—CRP正常组（54例。33．7％、8．2％、5．1％）多见（P〈0．05）。结论：hs-CRP水平与冠状动脉局部斑块性质有关，hs—CRP升高者冠状动脉局部斑块不稳定的危险性增高。

Study on the Relationship between Plaque Features by Intravascular Ultrasound and High-sensitivity C-reactive Protein Level in Patients with Unstable Angina

Objective： To observe the relationship between sermn high-sensitivity C-reactive protein（hs-CRP）level and plaque features by intravaseular ultrasound（IVUS） in patients with unstable angina（UAP）. Methods： Ninety-eight UAP were enrolled in this study. Hs-CRP was determined 24 hours before coronary arteriography followed by IVUS evaluation in target lesion. The relationship between serum hs-CRP level and plaque features by IVUS was analyzed. Results： Compared to normal hs-CRP group, there were more soft plaques in the hs-CRP group（36.7% vs 33.7%, P 〈 0.05）, plaque rupture （ 15.3 % vs 8.2 %, P 〈 0.05）, and thrombogenesis in coronary stenosis（ 11.2 % vs 5.1%, P 〈 0.05）, respectively. Conclusion： Hs-CRP is a reliable marker to predict the stability of coronary artery plaque.