喂饲克山病病区粮大鼠全血GSH－Px活力的动态变化及硒和维生素E的影响

本文应用低硒的克山病病区粮喂饲大鼠并在其中补充一定剂量的硒或维生素Ｅ（ＶＥ），观察其对全血ＧＳＨ－Ｐｘ活力的动态影响。实验结果表明，喂饲病区粮６周时，ＧＳＨ－Ｐｘ活力大幅度降低，并一直保持在最低水平。１０周时在缺氧因素（ＮａＮＯ２）影响下，ＧＳＨ－Ｐｘ活力进一步明显下降。在病区粮中补一定剂量硒，２周时酶活性显著提高，４周时提高了１００％并保持在较高水平。联合补硒和ＶＥ的作用优于单纯补硒。在ＮａＮＯ２作用情况下，补硒或补ＶＥ组ＧＳＨ－Ｐｘ未出现明显降低，提示其对缺氧性损害的抵抗力增强，此作用亦以联合补硒和ＶＥ的效果最佳。

Effects of selenium and vitamin E on the dynamic changes of GSH-Px activity in blood of rats fed with grains from Keshan disease endemic area

The dynamic changes of the GSH-Px activity in blood of rats fed with grainsfrom Keshan disease endemic area and the effects of selenium and vitamin E on them were inves-tigated.The results demonstrated that the GSH-Px activity in rats from endemic grain group de-creased markedly by the end of first six weeks and remained in the lowest level.Diet supplement-ed with selenium(0.44mg/kg·d)statisticaly increased the GSH-Px activity in the first twoweeks,and GSH-Px activity reached two times by the end of the first four weeks and remainedin the high level.Diet supplemented with both seleniu and vitamin E(500mg/kg·d)increasedthe GSH-Px activity more markedly than diet supplemented with only selenite did. By the end ofexperiment,the GSH-Px activity in rats being kept on the diet from Keshan disease endemic areastill further decreased under anoxia conditions.Both selenium and vitamin E increased the resis-tance to the lesions of anoxia and peroxidation more than the selenium alone did.