| 电穿孔疗法在头颈癌治疗中的应用 |
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| 引用本文： | 米彦,姚陈果,熊兰,孙才新,胡丽娜. 电穿孔疗法在头颈癌治疗中的应用[J]. 国际生物医学工程杂志, 2001, 24(5): 234-238 |
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| 作者姓名： | 米彦 姚陈果 熊兰 孙才新 胡丽娜 |
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| 作者单位： | 1. 重庆大学电气工程学院
2. 重庆医科大学第二附属医院 |
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| 基金项目： | 国家自然科学基金资助项目 (5 0 0 770 2 7) |
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| 摘 要： | 头颈癌严重地威胁着人类生命 ,而传统的化学治疗方法由于受癌细胞对药物吸收率的限制 ,其疗效也受到限制。电穿孔由于能使细胞膜出现暂时微孔 ,从而能大大提高癌细胞对药物的吸收率。在此基础上 ,结合传统的化疗方法形成的电穿孔疗法成为一种新型的头颈癌治疗法。博来梅素由于其自身的优良特性成为电穿孔疗法的首先药物。离体实验和临床研究表明 ,与传统方法相比 ,电穿孔疗法对于治疗头颈癌能取得更好的疗效
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| 关 键 词： | 头颈癌 电穿孔 电穿孔疗法 临床研究 |
| 文章编号： | 1001-1110(2001)05-0234-05 |
| 修稿时间： | 2001-04-29 |
The application of electroporation therapy in the treatment of head and neck cancer |
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| MI Yan,YAO Chen guo,XIONG Lan,SUN Cai xin. The application of electroporation therapy in the treatment of head and neck cancer[J]. International Journal of Biomedical Engineering, 2001, 24(5): 234-238 |
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| Authors: | MI Yan YAO Chen guo XIONG Lan SUN Cai xin |
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| Abstract: | Human life is imperiled seriously by head and neck cancer (HNC),and the curative effect of conventional chemotherapy is hardly limited by the limited absorbing rate for drug.Electroporation can greatly enhance the membrane permeability because it can induce transient pores in cell membranes.The combination of chemotherapy and electroporation which is called electroporation therapy(EPT)becomes a novel treatment of HNC,and bleomycin becomes the preferred EPT drug because of its outsanding characteristics.On the basis of clinical research,we can draw a conclusion that EPT is a more effective treatment of HNC comparing with conventional treatment. |
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| Keywords: | head and neck cancer electroporation electroporation therapy clinical research |
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