| 内质网未折叠蛋白反应与凋亡信号机制研究进展 |
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| 引用本文： | 马涛,薛承锐.内质网未折叠蛋白反应与凋亡信号机制研究进展[J].医学综述,2008,14(23):3565-3567. |
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| 作者姓名： | 马涛 薛承锐 |
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| 作者单位： | 天津医科大学总医院中西医结合外科,天津,300052 |
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| 基金项目： | 天津市自然科学基金
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| 摘 要： | 内质网是细胞内蛋白质合成、折叠的重要场所。低氧、葡萄糖饥饿、氧化和糖基化作用紊乱等刺激下,未折叠或折叠错误的蛋白质会积聚于内质网内,导致内质网应激反应。上调内质网伴侣蛋白表达、减轻内质网负担等机制可以恢复细胞内环境的稳态,但严重或持久的内质网应激反应通过caspase-12、JNK及CHOP等机制启动细胞凋亡程序。本文综述了细胞保护反应中内质网未折叠蛋白反应及其诱导凋亡信号的研究进展。
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| 关 键 词： | 内质网 应激 非折叠蛋白质反应 细胞凋亡 |
Endoplasmic Reticulum Stress and Apoptosis |
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| MA Tao,XUE Cheng-rui.Endoplasmic Reticulum Stress and Apoptosis[J].Medical Recapitulate,2008,14(23):3565-3567. |
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| Authors: | MA Tao XUE Cheng-rui |
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| Institution: | Department of Surgery of Combined Chinese and Western Medicine;General Hospital;Tianjin Medical University;Tianjin 300052;China |
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| Abstract: | The endoplasmic reticulum (ER) is the cellular site of protein synthesis and folding.Stimulated by hypoxia,glucose starvation,oxidation and glycosylation disorder,unfolded and wrongly folded protein would accumulate in ER and result in ER stress reaction,and then up-regulate chaperone protein of ER,decrease the burden of ER to restore the stable environment.When the unfolded protein response (UPR)is perturbed or not sufficient to deal with the stress conditions,apoptotic cell death is initiated.This review ... |
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| Keywords: | Endoplasmic reticulum Stress Unfolded protein response Apoptosis |
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