心肌缺血预处理对心肌保护作用的临床分析

目的 :探讨心肌缺血预处理 (IP)对心肌梗死后心肌保护作用。方法 :对 15 4例 ST段抬高的急性心肌梗死 (AMI)患者临床资料进行回顾性分析 ,其中 78例心肌梗死前有心肌缺血预处理 (A组 )与 76例无心肌缺血预处理 (B组 )。观察梗死前心肌缺血预处理对心肌梗死后泵功能、复杂室性期前收缩及梗死面积的影响。结果 :A组泵功能障碍、复杂室性期前收缩发生率及肌酸磷酸激酶 (CPK)与肌酸磷酸激酶同功酶 MB(CK- MB)峰值显著低于 B组 (P <0 .0 5～ 0 .0 0 1)。结论 :心肌缺血预处理具有保护心肌、缩小梗死范围、减轻泵功能不全及降低心律失常发生率的作用。

The clinical analysis on the effect of myocardial protection of ischemic preconditioning

Objective:To observe the myocardial protection of ischemic preconditioning (IP) after AMI Methods:The clinical data of a total of 154 consecutive patients with ST segment elevation AMI were analysised,including group A (78 patients,ischemic preconditioning before AMI) and group B (76 patients,no ischemic preconditioning before AMI).The effect of ischemic preconditioning were observed before AMI on the infarct size,ventricular arrhythmias and cardiac function Results:It was found that group A had lower incidences of cardiac dysfunction and ventricular arrhythmias.The peak values of CPD and CK MB in group A were significantly decreased Conclusion:The IP may preserved myocardial,limite the infarct size,preserve the cardiac function and decrease ventricular arrhythmias