新生儿败血症耐甲氧西林凝固酶阴性葡萄球菌的检测

①目的 探讨耐甲氧西林凝固酶阴性葡萄球菌（MRCNS）在新生儿败血症中的分布及耐药性特点。②方法 应用全自动血培养系统（BACTE/9050）、ATB细菌鉴定仪，对40例MRCNS感染新生儿败血症血培养进行细菌鉴定；应用ATB药敏系统，测定MRCNS对青霉素等17种抗生素的耐药性。③结果 40株MRCNS中溶血葡萄球菌17株（42.5%），表皮葡萄球菌15株（37.5%），其他葡萄球菌8株（20.0%）。药敏结果显示MRCNS多重耐药，万古霉素及其他糖肽类抗生素是治疗MRCNS感染的首选药物。④结论 凝固酶阴性葡萄球菌（CNS）为新生儿败血症的主要致病菌。

A DETECTION OF MRCNS IN NEONATAL SEPTICEMIA

Objective\ To discuss the distribution and the features of drug resistance of MRCNS infections in neonates. Methods\ Blood specimens taken from 40 neonates with MRCNS were cultured and identified using the total automatic blood culture system and ATB bacteria identification instrument. The resistance of MRCNS to 17 antibiotics, including penicillin, was detected using ATB antimicrobial susceptibility testing system.\ Results\ Among the 40 MRCNS strains, there were 17 S.hemolyticus strains (42.5%), 15 S.epidemidis strains(37.5%) ,and 8 other kinds of staphylococcus strains(20.0%). The MRCNS showed multidrug resistance. Vancomycin and some other glycopeptide antibiotics were the first choice for MRCNS infections. Conclusion\ CNS were the major causative germs for septicemia in neonates.