心肌缺血动物模型经皮激光血运重建术后心肌灌注与病理结果分析

目的：阐明经皮激光心肌血运重建术可能的治疗机制。方法：杂种健康犬40只，建立心肌缺血动物模型；L组送入导管室，进行标准前降支部位PMR操作，C组对照；两组分别于SPECT心肌灌注扫描后处死，取心肌组织制作病理标本。结果：PMR后L组改善率68．3％，明显高于C组，未改善率和变坏率明显低于C组；病理组织切片显示激光孔道通畅率各时间点分别为89％，53％，42％，34％和25％。结论：PMR治疗缺血的机制是多种因素共同作用的结果。

A Machanism Study of PMR Procedure by 99mTc-MIBI SPECT and Pathology in the Myocardial Ischemia Animals

Objective To investigate the machanism of PMR percedure.Methods After fourty mongrel dogs underwent thoracotomy, myocardial ischemia animal models had been established. The laser catheler was inserted into LV via a guider and myocardial channels were completed in the L group. Before and after PMR procedure, 99m Tc MIBI SPECT and pathologic slice were compared. Results There were improvement of 68.3% in the myocardial perfusion after PMR in the L group. Laser channels of 89%, 53%, 42%, 34%, 25% were opened.Conclusion The machanism of PMR procedure is very complicated, and it include many facters.