温阳健心灵口服液治疗收缩功能不全性心力衰竭的临床研究 |
| |
引用本文: | 吴时达,吴桐,吴昌碧,蒲琳,陈琳,汤雁蓉,李伟,黄永诚,庄建军.温阳健心灵口服液治疗收缩功能不全性心力衰竭的临床研究[J].中国中西医结合急救杂志,2001,8(2):88-91. |
| |
作者姓名: | 吴时达 吴桐 吴昌碧 蒲琳 陈琳 汤雁蓉 李伟 黄永诚 庄建军 |
| |
作者单位: | 四川省成都市第一人民医院, |
| |
基金项目: | 国家中医药管理局科研基
金资助项目(No.95A2112) 获奖项目:四川省中医药管理局中医药科技进步三等奖(No.200031
11) 四川省成都市政府科技进步三等奖(No.973153) |
| |
摘 要: | 目的:了解温阳健心灵口服液(WYJXLD)对收缩功能不全性心力衰竭(心室)的疗效。方法:120例患者随机分2组,实验组给WYXJXLD、对照组给予开搏通治疗,疗程均为2周。治疗前后均做多普勒超声心功能检查,部分患者做心钠素(ANF)、内皮素(ET)和甲状腺激素FT3、FT4)测定。治疗后按后卫生部颁布的《中药新药治疗充血性心衰指导原则》进行疗效判定。结果:实验组总有效率67.8%,对照组60.0%,2组疗效经Ridit分析显著差异,实验组治疗后心脏收缩功能指标如射血分数(ET)用左心室后壁增厚率(△T%)]明显增加(P<0.01);另外;对伴舒张功能不全者,其A/E比值和A峰也明显下降(P<0.05)。上述心功能指标的改善均优于对照组(P均<0.05)。实验组心脏舒张功能的改善似从属于收缩功能的改善,在改善心功能的同时,实验组ANF和FT3也明显升高(P<0.05)。FT3的提高和心功能改善明显相关,而FT4的提高和心功能改善的关系不大。结论:WYJXLD对收缩人功能不全性心衰有良好的近期疗效。
|
关 键 词: | 温阳健心灵口服液 心力衰竭 收缩功能不全性 中医药疗法 |
文章编号: | 1008-9691(2001)02-0088-04 |
修稿时间: | 2001年1月6日 |
Clinical observations on
treatment with Wenyang Jianxin L ing drink( |
| |
Abstract: | Objective:To study the curative effect of Wenyang Jianxin Ling drink(WYJXLD,温阳健心灵口服液) on deficient systolic heart failure.Methods:One hundred and twenty patients were randomly divided into two groups,they were given WYJXLD(trial group) or captopril(control group) respectively for 2 weeks.The cardiac function was evaluated by Doppler echocardi ography in all pa tients and the levels of atrial natriuretic factor(ANF),endoth elin(ET) and free triiodothyronine(FT3),free thyroxine(FT4) before and afte r t reatment were measured in partial patients separately.The curative effect was j udged by the 《Guideprinciple of Traditional Chinese Medicine Treati ng Congestive Heart Failure》 published by the Public Health Department.Results:Two groups had no difference in effective rate by Radit analyse (67.8% vs.60. 0%).The indexes about systolic function such as ejection fraction(EF) and the t h ickening rate of left ventricular posterior wall were significantly increased in trial group(P<0.01).The A/E ratio and peak Awave were decr eased obviously in cases who had diastolic heart failure simultaneously in trial group (P<0.05).The improvement of abovementioned cardiac function indexes in trial group were superior to those in control group (P< 0.05).The improvement of the diastolic function seemed to subordinate to the improveme nt of systolic function. With the improvements of cardiac functions the ANF, FT 3 and FT4 were obviously increased in trial group.Regarding the thyroid h ormone the increase in FT3 was markedly related to the improvement of cardiac function but the increase in FT4 was not.Conclusions:WYJXLD has good shortterm curative effect on systolic heart failure in the near future. |
| |
Keywords: | Wenyang Jianxin Ling drink deficient systolic heart failure ejection fraction thyroid hormone atrial natriuretic factor endothelin traditional Chinese medicine |
本文献已被 维普 万方数据 等数据库收录! |