| 前列腺癌的神经内分泌分化 |
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| 引用本文： | Jingwen Wang Yang Yao. 前列腺癌的神经内分泌分化[J]. 中德临床肿瘤学杂志, 2008, 7(3): 150-153. DOI: 10.1007/s10330-007-0184-3 |
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| 作者姓名： | Jingwen Wang Yang Yao |
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| 作者单位： | Jingwen Wang（Department of Oncology, Shanghai Sixth People's Hospital, Jiaotong University, Shanghai 200233, China） Yang Yao（Department of Oncology, Shanghai Sixth People's Hospital, Jiaotong University, Shanghai 200233, China） |
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| 摘 要： |
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| 关 键 词： | prostate cancer neuroendocrine differentiation drug resistance 前列腺癌 神经 内分泌分化 prostate cancer differentiation mechanism neuroendocrine relationship paper prognosis manifold neural peptide hormones lead growth tumor cells metastatic therapy treatment |
| 收稿时间： | 2007-11-27 |
| 修稿时间： | 2008-01-30 |
Neuroendocrine differentiation in prostate cancer |
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| Jingwen Wang,Yang Yao. Neuroendocrine differentiation in prostate cancer[J]. The Chinese-German Journal of Clinical Oncology, 2008, 7(3): 150-153. DOI: 10.1007/s10330-007-0184-3 |
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| Authors: | Jingwen Wang Yang Yao |
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| Affiliation: | (1) Department of Oncology, Shanghai Sixth People’s Hospital, Jiaotong University, Shanghai, 200233, China |
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| Abstract: | Hormonal therapy is an important treatment for advanced/metastatic prostate cancer. But it can induce neuroen-docrine (NE) differentiation in prostate cancer cells. These NE cells will secrete manifold neural peptide or hormones which can lead to androgen-independent growth of non-NE tumor cells. When this happens, hormonal therapy becomes useless and indicates bad prognosis. In this paper, the mechanism of neuroendocrine differentiation and its relationship with androgen-independent were reviewed. |
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| Keywords: | prostate cancer neuroendocrine differentiation drug resistance |
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