| CDK4 Fas在不同子宫内膜中的表达探讨 |
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| 引用本文： | 李会影,鞠建新.CDK4 Fas在不同子宫内膜中的表达探讨[J].微量元素与健康研究,2011,28(2):8-10. |
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| 作者姓名： | 李会影 鞠建新 |
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| 作者单位： | 牡丹江医学院红旗医院妇产科,黑龙江,牡丹江,157000 |
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| 摘 要： | 目的:探讨CDK4(cyclin dependent kinase 4)周期素依赖性激酶4,Fas/Apo-1蛋白在不同子宫内膜中的表达及意义。方法:采用免疫组织化学SP法,测定12例正常子宫内膜16例不典型增生子宫内膜及40例子宫内膜癌中的CDK4蛋白与Fas蛋白的表达情况。结果:CDK4在不典型增生子宫内膜和子宫内膜癌中的阳性表达率与正常组相比均有显著性差异(P<0.05),Fas蛋白在子宫内膜癌(endometrial carcinoma,EC)中的表达明显低于正常子宫内膜,差异有显著性(P<0.05)。结论:CDK4蛋白的过度表达可能在子宫内膜癌的发生、发展、浸润中具有一定作用,还可能作为一种有价值的肿瘤标志物。Fas蛋白在子宫内膜癌中的低表达提示其可能通过调控细胞凋亡参与了子宫内膜癌的发生和发展,可能与子宫内膜癌细胞的凋亡及免疫逃避等密切相关。
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| 关 键 词： | CDK4蛋白 Fas蛋白 子宫内膜 免疫组化 |
Expression of CDK4 protein and Fas indifferent endometrium and its clinical significance |
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| LI Hui-ying,JU Jian-xin.Expression of CDK4 protein and Fas indifferent endometrium and its clinical significance[J].Studies of Trace Elements and Health,2011,28(2):8-10. |
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| Authors: | LI Hui-ying JU Jian-xin |
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| Institution: | LI Hui-ying,JU Jian-xin (Department of Gynecology and Obsteric,HongQi Affiliated Hospital,Mudanjiang Medical College,Heilongjiang Mudanjiang 157000,China) |
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| Abstract: | Objective:To investigate the expressions of CDK4 and Fas proteins in different endometrium.Methods:A specific and sensitive immunohistochemical SP assay was used to detect the expression of CDK4 and Fas protein in 40 cases of endometrial carcinoma,16 atypical hyperplasia of endometrium and 12 normal endometrium.Results:Both the CDK4 positive rates in atypical hyperplasia of endometrium and in cancer were significantly higher than that in normal endometrium(P<0.05).The expression of Fas in EC was significant... |
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| Keywords: | CDK4 Fas protein endometrum immunohistochemistry |
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