子痫前期患者血清中sFlt-1水平的研究

目的:通过对子痫前期患者血清中的可溶性血管内皮生长因子受体1(soluble fms-like tyrosine kinase-1,sFlt-1)的表达水平的测定,探讨它与子痫前期发病的关系及意义。方法:选取子痫前期患者40例,其中包括轻度子痫前期10例和重度子痫前期30例,同时选取同期正常孕妇40例,采用酶联免疫吸附试验(ELISA)夹心法检测三组孕妇血清中的sFlt-1的水平。结果:子痫前期组血清sFlt-1为939.27±109.48ng/L,正常妊娠组为279.24±147.39ng/L,两组比较差异有统计学意义(P<0.01)。重度子痫前期组血清中sFlt-1为941.76±159.01ng/L,轻度子痫前期组血清中sFlt-1为928.13±141.27ng/L,两组比较差异无统计学意义(P>0.05)。结论:母体血清sFlt-1水平在正常妊娠组和子痫前期组之间是有明显差异的,但是与子痫前期的严重程度没有直接关系。

Study of serum sFlt-1 levels in patients with preeclampsia

Objective: To observe the level of serum soluble fms-like tyrosine kinase-1(sFlt-1) in patients with preeclampsia Methods: 40 patients with preeclampsia were collected.Among them,10 cases were mild preeclampsia and 30 cases were severe preeclampsia.40 healthy pregnant women were selected as control.The serum level of sFlt-1 in the three groups was measured by using enzyme-linked immunosorbent assay(ELISA).Results: The serum level of sFlt-1 was 939.27±109.48ng/L in preeclampsia group and 279.24±147.39ng/L in normal group(P<0.01).The serum level of sFlt-1 was 941.76±159.01ng/L in severe preeclampsia group and 928.13±141.27ng/L in mild preeclampsia group.There was no statistical significant difference between the two groups of patients with preeclampsia(P>0.05).Conclusion: Serum sFlt-1 level was significantly increased in patients with preeclampsia.However it is not directly related to the severity of preeclampsia.