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| 降糖保肾汤对糖尿病肾病大鼠肾组织内氧化损伤的影响 | |
| 引用本文： | 张雨薇,郝营丽,王岩姝,苏小悦,夏学丽.降糖保肾汤对糖尿病肾病大鼠肾组织内氧化损伤的影响[J].牡丹江医学院学报,2012,33(1):3-5. |
| 作者姓名： | 张雨薇 郝营丽 王岩姝 苏小悦 夏学丽 |
| 作者单位： | 1. 黑龙江中医药大学生理教研室 黑龙江哈尔滨 150040 2. 铁力市人民医院药剂科 黑龙江铁力 152500 3. 哈尔滨市香坊区65429部队卫生队 黑龙江哈尔滨 150046 |
| 摘 要： | 目的:观察降糖保肾汤(jiang tang bao shen decoction,JTBSD)对糖尿病(diabetes mellitus,DM)大鼠血糖、肾组织内氧化损伤的影响。方法:采用单次腹腔注射链脲佐菌素(Streptozotocin,STZ)建立DM大鼠模型。大鼠随机分为四组:正常组、模型组、JTBSD组、盐酸贝那普利(Benazepril hydrochloride,BNPH)组。给药12周,取肾脏用比色分析法测定肾组织内超氧化物歧化酶(superoxide dismutase,SOD)的活性以及丙二醛(malondialdehydiee,MDA)的含量。结果:JTBSD能明显降低DM大鼠的血糖水平,能够显著提高肾组织SOD水平和降低肾组织MDA的含量。结论:JTBSD对DM大鼠肾组织具有抗氧化损伤能力的作用。 |
| 关 键 词： | 糖尿病 肾病 抗氧化 |
EFFECTS OF JIANGTANG BAOSHEN DECOCTION ON OXIDATIVE DAMAGE OF KIDNEY TISSUE IN DIABETIC NEPHROPATHY RATS |
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| Institution: | Zhang Yu-Wei et al(Department of Physiology,Basic Medical College of Heilongjiang traditional Chinese medicine University,Haerbin 150040,China) |
| Abstract: | Objective:to observe the effects of Jangtang Baoshen decoction(JTBSD) on blood glucose and oxidative damage in Diabetic Nephropathy rats.Methods:The experimental model of diabetic rats were established by injecting intraperitoneally streptozotocin(STZ).Mellitus were divided into four groups:nomal、model、JTBSD、(Benazepril hydrochloride,BNPH).(superoxide dismutase,SOD)and(malondialdehyde,MDA)from kidney were measured with colorimetric method after intragastric administration with the JT BSD 30 m L/kg fo r 12 weeks.Results:afer applicate JTBSD,blood glucose was decreased significantly,the level of SOD was increased significantly,MDA was decreased significantly.Conclusion:JTBSD has significant effect of antioxidative damage on DM rats kidney tissue. |
| Keywords: | diabetes nephropathy antioxidation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |