| P物质、血管活性肠肽在口腔扁平苔藓唾液中的表达 |
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| 引用本文： | 黎春晖,彭为,李洪平,聂敏海. P物质、血管活性肠肽在口腔扁平苔藓唾液中的表达[J]. 泸州医学院学报, 2012, 35(1): 21-22 |
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| 作者姓名： | 黎春晖 彭为 李洪平 聂敏海 |
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| 作者单位： | 1. 泸州医学院附属口腔医院口腔内科,四川泸州,646000
2. 遂宁市中心医院口腔颌面外科 |
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| 摘 要： | 目的:检测P物质(SP)、血管活性肠肽(VIP)在口腔扁平苔藓(OLP)唾液中的表达,并探讨SP、VIP与OLP的关系。方法:采用酶联免疫吸附法(ELISA)检测16例口腔扁平苔藓和正常人唾液中SP、VIP的含量。结果:SP在OLP患者唾液中的含量与正常人唾液中的含量无差异(P>0.05),VIP在OLP患者唾液中的含量高于正常人唾液中含量(P<0.05)。结论:OLP唾液中VIP的表达增高,唾液取材方便,唾液中的VIP含量的测定可能对OLP的疗效检测和预示复发有一定的临床应用价值。
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| 关 键 词： | 口腔扁平苔藓 P物质 血管活性肠肽 酶联免疫吸附法 |
STUDY OF THE EXPRESSION OF SUBSTANCE P AND VASOACTIVE INTESTINAL PEPTIDE IN ORAL LICHEN PLANUS SALIVA |
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| Affiliation: | Li Chunhui,et al Department of Oral Medicine,the Affiliated Hospital of Stomatology of Luzhou Medical College |
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| Abstract: | Objective:To examine the expression of substance P(SP) and vasoactive intestinal peptide(VIP) in oral lichen planus(OLP) saliva samples,and investigate the relationship between them and OLP.Methods:The concentration of SP and VIP in 16 OLP and normal saliva samples was assayed by ELISA.ReSUlts:The difference of SP concentration in saliva of OLP patients and control group was not significant(P>0.05).The difference of VIP concentration in saliva between OLP patients and control group was significant(P<0.05),which meant saliva VIP concentration was higher in OLP patients than in control group.Conclusion:The expression of VIP increased in saliva of OLP patients.Moreover,the collection of saliva samples is convenient in clinic.The determination of saliva VIP may be helpful to monitor therapy and predict recurrence for OLP patients. |
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| Keywords: | Oral lichen planus Substance P Vasoactive intestinal peptide Enzyme-linked immunosorbent assay |
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