| eNOS基因多态性与成人过敏性紫癜的关系 |
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| 引用本文： | 安锦丹,于晶,梅松柳,王洪伟,展涛,杨国荣,郭素芬,曹永,颜彬.eNOS基因多态性与成人过敏性紫癜的关系[J].牡丹江医学院学报,2012,33(1):1-3. |
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| 作者姓名： | 安锦丹 于晶 梅松柳 王洪伟 展涛 杨国荣 郭素芬 曹永 颜彬 |
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| 作者单位： | 1. 牡丹江医学院病理教研室 黑龙江 牡丹江 157011
2. 牡丹江医学院附属红旗医院肾内科 黑龙江牡丹江 157011 |
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| 基金项目： | 黑龙江省卫生厅科研项目，牡丹江市科学技术计划项目 |
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| 摘 要： | 目的:探讨内皮型一氧化氮合酶基因G894T多态性与过敏性紫癜和过敏性紫癜性肾炎易感性的关系。方法:应用PCR-RFLP技术检测90例过敏性紫癜/过敏性紫癜性肾炎患者与98例正常对照组内皮型一氧化氮合酶基因G894T多态性。结果:eNOS基因型构成比在HSP组与正常对照组、HSPN组与正常对照组之间差异有显著性(P=0.022,P=0.025),但在HSP和HSPN之间差异无显著性(P=0.585)。eNOS-GG基因型和G等位基因具有较高的患HSP和HSPN的危险性。结论:携带eNOS基因G894T多态性增加患HSP/HSPN的危险。
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| 关 键 词： | 过敏性紫癜 过敏性紫癜性肾炎 内皮型一氧化氮合酶 基因多态性 |
ASSOCIATION OF ENOS GENE POLYMORPHISM WITH GENETIC SUSCEPTIBILITY TO HENOCH-SCHONLEIN PURPURA |
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| Institution: | AN Jindan et al(Department of Pathology,Mudanjiang Medical University,Mudanjiang 157011 china) |
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| Abstract: | Objective:To explore the relationship between G894T gene polymorphism of Endothelial nitric oxide synthase(eNOS) gene and Henoch-Schonlein purpura(HSP).Methods:G894T polymorphism of eNOS gene was analyzed in 90 atients with HSP/HSPN and 98 healthy adults served as control by using PCR-RFLP.Results:The eNOS genotype distribution was significantly different between HSP and normal control,and between HSPN and normal control(P=0.022,P=0.025),but no difference was observed between HSP and HSPN(P=0.585).The eNOS gene GG genotype and G allele has has a high risk for HSP and HSPN.Conclusion:eNOS gene G894T polymorphism is associated with HSP/HSPN. |
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| Keywords: | Henoch-Schonlein purpura(HSP) Henoch-Schonleinpurpura nephritis(HSPN) Endothelial nitric oxide synthase(eNOS) Polymorphism |
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