The role of human papillomavirus in head and neck cancer and the impact on radiotherapy outcome |
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| Authors: | Xiaoyuan Zhu Ying Wang Honghai Zhu Weihua Lou |
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| Institution: | Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China |
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| Abstract: | Conclusion: HPV?+?HNSCC patients have improved Overall Survival (OS), Disease Specific Survival (DSS), Disease Free Survival (DFS), and Progression Free Survival (PFS). The radiotherapy treatment can’t improve the Survival of the HPV-negative HNSCC patients.Objective: To investigate the role of Human papillomavirus in head and neck cancer and the impact on radiotherapy outcome.Methods: A search in PubMed and Chinese CNKI (2000–2015) was performed. This meta-analysis was done using RevMan 5.1 software. Outcomes included OS, DSS, DFS, PFS, and Treatment responses rates (RR).Results: A total of 2620 patients in 10 studies were included. The Positive detective rates of HPV and P16 are 32.5% (425/1309) and 42.5% (526/1239). OS and PFS were improved in HPV?+?patients compared to HPV???patients (HR?=?0.48; 95% CI?=?0.37–0.62, p?p?p?p?p?= 0.05). |
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| Keywords: | Head and neck cancer human papillomavirus radiotherapy |
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