Unresectable Locally Advanced Pancreatic Cancer: A Multimodal Treatment Using Neoadjuvant Chemoradiotherapy (Gemcitabine Plus Stereotactic Radiosurgery) and Subsequent Surgical Exploration |
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| Authors: | Francesco Polistina Giorgio Costantin Franco Casamassima Paolo Francescon Rosabianca Guglielmi Gino Panizzoni Antonio Febbraro Giovanni Ambrosino |
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| Affiliation: | (1) Department of Surgery, San Bortolo Hospital, Vicenza, Italy;(2) Clinical Radiological Institute, University of Florence, Florence, Italy;(3) Service of Medicine Applied Physics, San Bortolo Hospital, Vicenza, Italy;(4) Section of Radiotherapy, San Bortolo Hospital, Vicenza, Italy;(5) Department of Oncology, Fatebenefratelli Hospital, Benevento, Italy;(6) School of General Surgery, University of Padua, Padua, Italy;(7) Department of Medical and Surgical Emergencies, Dolo Hospital, Dolo, Venice, Italy |
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| Abstract: | Background Pancreatic cancer accounts for approximately 3% of cancer deaths in Europe. Locally advanced pancreatic cancer (LAPC) involves vascular structures, and resectability is low, with a median survival time of 6 to 11 months. We conducted a prospective, nonrandomized study of patients with LAPC to assess the effect of stereotactic body radiotherapy (SBRT) on local response, pain control, and quality of life (QOL). |
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