空腹血糖与冠状动脉病变程度的相关性

目的探讨空腹血糖（FPG）水平与冠状动脉（下称冠脉）病变程度的相关性。方法回顾分析913例高度怀疑冠心病（CHD）而行冠脉造影的患者的临床资料,冠脉造影病变程度由是否诊断CHD、冠脉病变支数和冠脉病变Gensini总积分三方面表示。对FPG水平与冠脉病变程度进行单因素和多因素分析。结果FPG与冠脉病变程度密切相关：（1）Logistic回归结果显示FPG与冠脉有无病变显著相关（OR值1.462,95%CI为1.178~1.813,P〈0.01）;（2）多元逐步回归结果显示在校正了年龄、性别等因素之后,FPG与冠脉病变支数（r=0.164,P〈0.01）、冠脉病变总积分（r=0.088,P〈0.05）仍然独立相关。随着FPG的升高,冠脉病变支数增加。结论冠心病高危人群的FPG水平与冠脉病变程度密切相关,即使在糖尿病前期,随着FPG升高,冠脉病变程度也更加严重。

The relationship of the extent and severity of angiographic coronary artery disease with fasting plasma glucose

Objective To evaluate the correlation of fasting plasma glucose with the extent and severity of angiographic coronary artery disease （CAD） in patients who underwent coronary angiography. Methods A total of 913 consecutive patients who underwent coronary angiography were selected in the study. The extent and severity of angiographic CAD were diagnosed by; （1） whether or not with CAD diagnosis by angiography; （2） the number of diseased vessels; （3） The CAD Gensini cumulative index. Data were analyzed by univariate and multivariate analyses. Results Multivariate analysis showed that the fasting plasma glucose had significant correlation with the extent and severity of angiographic coronary artery disease,which reasons included： （1）The FPG had significant correlation with the diagnosis or not of CAD by angiography（OR= 1. 462,95% CI： 1. 178 - 1. 813, P = 0. 001） ; （2） After adjusting age, sex and other influencing factors, FPG had significant correlation with the number of diseased vessels （r=0. 164, P〈0.01） and with the CAD Gensini cumulative index（r=0. 088, P〈0.05）. Univariate analysis revealed that the number of diseased vessels was increased along with the increasing FPG even in prediabetic period. Conclusions The extent and severity of angiographic coronary artery disease have significant correlations with the fasting plasma glucose, and the extent and severity can increase along with the increasing FPG even in prediabetic period.