吸入糖皮质激素治疗稳定期慢性阻塞性肺病的疗效

目的：探讨吸入糖皮质激素治疗稳定期慢性阻塞性肺病的临床疗效.方法：将98例稳定期慢性阻塞性肺病患者按数字表法随机分为两组,对照组进行氧疗、祛痰以及按需吸入沙丁胺醇等常规治疗,观察组患者在对照组治疗的基础上吸入布地奈德（一种非卤素糖皮质激素）气雾剂进行治疗,比较两组患者治疗前后肺功能、呼吸困难评分、临床症状评分、生活质量评分、临床总有效率和不良反应发生率.结果：治疗后观察组的肺功能以及呼吸困难评分、临床症状评分、生活质量评分的改善情况明显优于对照组;观察组总有效率为93.88％,明显高于对照组的75.51％,差异均具有统计学意义（x2=9.87,P＜0.05）,而不良反应率分别为18.37％、16.33％,差异无统计学意义（x2=3.12,P＞0.05）.结论：吸入糖皮质激素治疗稳定期慢性阻塞性肺病的疗效优于常规治疗,可改善患者临床症状,提高生活质量,不良反应少.

The Curative Effects of Corticosteroid Inhalation in Stable Chronic Obstructive Pulmonary Disease

Objective： To explore the curative efficacy of corticosteroid inhalation in treating stable chronic obstructive pulmonary disease （COPD）. Methods： A total of 98 patients with stable COPD were randomly divided into two groups by using digital table method. The control group was given con- ventional treatment such as oxygen therapy, expectorant and inhalation salbutamol based on demand. Observation group was given budesonide aerosol inhalation in addition to the treatment of control group. Pulmonary function and dyspnea scores, clinical symptom scores, life quality scores, total effective rate and adverse reaction incidence of the two groups were observed and compared before and after treatment. Results： After treatment, the improvement of lung function, dyspnea scores, clinical symp- tom scores and life quality scores was more obvious than that of control group. The total effective rate of observation group （93.88%） was significantly higher than that of control group （75.51%）, the difference was statistically significant （X2 = 9. 87, P 〈 0.05 ）. Adverse reaction rates of observation group and control group were 18.37% and 16.33% respectively, the difference was not statistically significant （X2 = 3. 12, P 〉 0.05 ）. Conclusions： The curative efficacy of corticosteroid inhalation in treating stable COPD is better than that of conventional treatment. Corticosteroid inhalation can im- prove the clinical symptoms and life quality and cause less adverse reaction.