脂联素、IL-6与老年脑梗死患者颈动脉中膜厚度的相关性

目的：研究老年脑梗死患者血清脂联素、白介素-6（IL-6）与颈动脉内膜中层厚度（IMT）的关系.方法：将193例脑梗死患者根据神经功能缺损评分分为轻、中、重度3组,并选择59例健康老年体检者设为对照组,比较不同程度脑梗死患者血清脂联素、IL-6水平及IMT的情况,研究血清脂联素、IL-6与IMT的相关性;给予脑梗死患者相应综合治疗,比较治疗前后脂联素、IL-6差异.结果：不同病变程度脑梗死各组及对照组脂联素、IL-6及IMT的差异均有统计学意义（P＜0.05）;脑梗死患者脂联素与IMT呈负相关（r=-0.526,P＜0.05）,IL-6与IMT呈正相关（r=0.618,P＜0.05）;脑梗死患者治疗前后脂联素、IL-6的差异均有统计学意义（P＜0.05）,治疗后患者血清脂联素升高,IL-6降低.结论：IL-6的表达及IMT的厚度随脑梗死病变程度加重而升高,IL-6与IMT呈正相关,脂联素的表达则随脑梗死病变程度加重而降低,且与IMT呈负相关.

Studies on Adiponectin,IL-6 and Old Cerebral Carotid Artery Intima-media Thickness for Correlation

Objective：To study the relationship among the levels of serum adiponectin,interleukin-6 （IL-6） and carotid artery intima-media thickness （IMT） in elderly patients with cerebral infarction （AP）,to explore the effect of serum adiponectin and IL-6 on senile cerebral infarction occurrence,development and prognosis.Methods：A total of 193 cases of cerebral infarction based on neurological deficit score were divided into mild,moderate and severe group.59 healthy elderly patients were selected as the control group,the relationship among the levels of serum adiponectin,IL-6 and IMT was analyzed,serum adiponectin levels,IL-6 levels and IMT of the three groups were compared before and after the treatment.Result：The differences of adiponectin,IL-6 and IMT of the three groups were statistically significant （P 〈 0.05） ; Adiponectin was negatively correlated with IMT in patients with cerebral infarction （r =-0.526,P 〈0.05）,IL-6 was positively correlated with IMT （r =0.618,P 〈 0.05） ; Adiponectin,IL-6 had significant difference before and after treatment in patients with cerebral infarction （P 〈 0.05）.After treatment serum adiponectin increased and IL-6 reduced.Conclusions：With the increasing degree of cerebral infarction,IL-6 and IMT increase,IL-6 is positively correlated with IMT,while adiponectin decreases with the increasing degree of cerebral infarction lesions,and is negatively correlated with IMT.Adiponectin and IL-6 have important clinical application value in evaluation of prognosis and monitoring the treatment in patients with cerebral infarction process