急性心肌梗死患者血浆中血小板P-选择素和血小板膜蛋白V的动态变化及其临床意义

目的 观察急性心肌梗死（AMI）患者血浆中血小板P-选择素（P-selectin）和血小板膜蛋白V（GPV）的动态变化，探讨急性心肌缺血前、后血小板活化的临床意义。方法 采用酶联免疫方法测定31例住院AMI患者发病12h内，第2d，第3d和1周时及30例正常人血浆中的P-selectin和GPV的含量，并对其动态变化进行比较。结果 AMI患者12h起P-selectin和GPV浓度明显高于正常组（P〈0．01），其中GPV当天达到高峰，P-selectin则在第2d达到高峰，第7d基本恢复正常范围（P〉0．05）。结论 GPV可以作为反映冠心病患者病程中血小板活化程度的一项新指标。

The Dynamic Changes of Platelet P-selectin and Glycoprotein Ⅴ in Acute Myocardial Infarction

Objective To investigate dynamic changes of plasma P-selectin(P-sel) and glycoprotein V(GPV) in Acute Myocardiac Infarction(AMI) and study the clinical signigicance of platelet activation before or after AMI.Methods The plasma P-selectin and GPV levels of 31 AMI in 12h,2 day,3 day and 7 day after infarction and 30 healthy people were measured by ELISA.Results The plasma P-selectin and GPV levels in AMI group were significant higher than that in the normal group(P<0.01),especially GPV levels on the first day and P-selectin levels on the second day after AMI reached the peak value.P-selectin and GPV levels decreased after AMI reached the peak value.P-selectin and GPV levels decreased to the normal range in the seventh day.Conclusions GPV can be regarded as a mark reflecting the degree of platelet activation in AMI patients.