| 选择性环氧合酶-2抑制剂对实验性胃溃疡大鼠胃黏膜增殖状态的影响 |
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| 引用本文： | 何美蓉,林劲秋,宋于刚,赖卓胜. 选择性环氧合酶-2抑制剂对实验性胃溃疡大鼠胃黏膜增殖状态的影响[J]. 中国现代医学杂志, 2008, 18(15): 2163-2165,2169 |
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| 作者姓名： | 何美蓉 林劲秋 宋于刚 赖卓胜 |
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| 作者单位： | 1. 南方医科大学南方医院,消化内科,广东,广州,510515
2. 南方医科大学护理学院,广东,广州,510515 |
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| 摘 要： | 目的 明确选择性环氧合酶-2(COX-2)抑制剂对实验性大鼠胃溃疡愈合的影响,并从胃黏膜增殖状态的角度探讨其延缓胃溃疡愈合的机制.方法 以乙酸性大鼠胃溃疡模型为基础,观察选择性COX-2抑制剂塞来昔布对胃溃疡愈合的影响及其对胃黏膜增殖细胞核抗原(PCNA)、肝细胞生长因子(HGF)及其受体c-Met蛋白表达的影响.结果 制模术后第9日,生理盐水组和塞来昔布组的溃疡面积分别为(11.9±3.1)mm2和(19.7±3.8)mm2(P<0.01);制模术后第6日和第9日,塞来昔布组PCNA标记指数(PCNA LI)和c-Met蛋白水平显著低于生理盐水组,而HGF蛋白水平差异则无显著性.结论 选择性COX-2抑制剂能显著延缓实验性大鼠胃溃疡的愈合,其机理之一可能是通过下调c-Met蛋白表达抑制胃黏膜上皮细胞的增殖.
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| 关 键 词： | 环氧合酶 胃溃疡 增殖细胞核抗原 肝细胞生长因子 |
Effect of selective COX-2 inhibitor on gastric epithelial cell proliferation in rats with experimental ulcer |
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| HE Mei-rong,LIN Jing-qiu,SONG Yu-gang,LAI Zhuo-sheng. Effect of selective COX-2 inhibitor on gastric epithelial cell proliferation in rats with experimental ulcer[J]. China Journal of Modern Medicine, 2008, 18(15): 2163-2165,2169 |
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| Authors: | HE Mei-rong LIN Jing-qiu SONG Yu-gang LAI Zhuo-sheng |
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| Affiliation: | HE Mei-rong1,LIN Jing-qiu2,SONG Yu-gang1,LAI Zhuo-sheng1 (1.Department of Gastroenterology,Nanfang Hospital,Nanfang Medical University,Guangzhou,Guangdong 510515,P.R.China,2.School of Nursing,P.R.China) |
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| Abstract: | [Objective] To determine whether selective COX-2 inhibitor affects the healing of experimental rats gastric ulcer and elucidate the mechanisms from the angle of gastric epithelial cell proliferation. [Methods] Acetic acid-induced ulcers were caused by application of acetic acid to the serosal surface of the anterior face of the rats gastric bodies, then the effects of the selective COX-2 inhibitor, Celecoxib, on the healing of gastric ulcer, and on the protein expression of PCNA, HGF, c-Met were observed. [... |
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| Keywords: | Cyclooxygenase gastric ulcer proliferative cell nuclei antigen hepatocyte growth factor |
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