从调节线粒体自噬角度探讨消渴病滋阴清热治法的科学内涵*

线粒体是进行三羧酸循环产生三磷酸腺苷（ATP）的主要场所，为生命活动提供能量。线粒体自噬指细胞通过自吞噬作用，选择性清除受损和冗余的线粒体，以维持细胞中线粒体质量和数量的稳定的一种保护机制。许多研究证实，线粒体功能失常引起的胰岛素抵抗和胰岛素分泌不足，直接参与了2型糖尿病（T2DM）的发生发展。阴虚燥热是消渴病的核心病机，其对应治法为滋阴清热，研究该治法的生物学实质，是客观了解T2DM中医微观辨证论治的关键一步。本文总结整理了线粒体自噬与T2DM的关系，并对线粒体自噬与消渴病滋阴清热治法的相关性进行综述。

The Scientific Connotation of Nourishing Yin and Clearing Heat in Treating Diabetes Based on the Perspective of Regulating Mitophagy

Mitochondria are the main organelle for the tricarboxylic acid cycle to produce adenosine triphosphate (ATP), which provides energy for life activities. Mitophagy is a protective Mechanism by which cells selectively remove damaged and redundant mitochondria through autophagy to maintain the stability of mitochondrial quality and quantity. Many researches have confirmed that insulin resistance and insufficient insulin secretion caused by mitochondrial dysfunction are closely related to the occurrence and development of type 2 diabetes mellitus(T2DM). Yin deficiency and dry heat is the central pathogenesis of diabetes, and nourishing Yin and clearing heat are the main treatment. The biological essence of the treatment is a key step to objectively understand the microscopic syndrome differentiation and treatment of T2DM in traditional Chinese medicine. In this article, the relationship between mitochondrial autophagy and T2DM was summarized, and the relationship between mitophagy and treatment of relieving T2DM and nourishing Yin and clearing heat was reviewed.