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The time to relapse correlates with the histopathological growth pattern in nodular lymphocyte predominant Hodgkin lymphoma |
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| Authors: | Sylvia Hartmann Annette Plütschow Anja Mottok Heinz-Wolfram Bernd Alfred C. Feller German Ott Sergio Cogliatti Falko Fend Leticia Quintanilla-Martinez Harald Stein Wolfram Klapper Peter Möller Andreas Rosenwald Andreas Engert Martin-Leo Hansmann Dennis A. Eichenauer |
| Affiliation: | 1. Senckenberg Institute of Pathology, Goethe University, Frankfurt am Main, Germany;2. First Department of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf, University of Cologne, Cologne, Germany German Hodgkin Study Group, University Hospital Cologne, Cologne, Germany;3. Institute of Pathology, University of Würzburg and Comprehensive Cancer Center (CCC) Mainfranken, Würzburg, Germany Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany;4. Hematopathology Lübeck, Lübeck, Germany;5. Department of Clinical Pathology, Robert-Bosch-Krankenhaus and Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany;6. Institute of Pathology, Kantonsspital St. Gallen, St. Gallen, Switzerland;7. Institute of Pathology, Eberhard Karls University Tübingen, Tübingen, Germany;8. Pathodiagnostic Berlin, Berlin Reference Center for Lymphoma and Hematopathology, Berlin, Germany;9. Institute of Pathology, Hematopathology Section and Lymph Node Registry, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany;10. Institute of Pathology, University Hospital Ulm, Ulm, Germany;11. Institute of Pathology, University of Würzburg and Comprehensive Cancer Center (CCC) Mainfranken, Würzburg, Germany;12. Senckenberg Institute of Pathology, Goethe University, Frankfurt am Main, Germany Reference and Consultation Center for Lymph Node and Lymphoma Pathology, Goethe University, Frankfurt am Main, Germany Frankfurt Institute of Advanced Studies, Frankfurt am Main, Germany |
| Abstract: | Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) can present with different histopathological growth patterns. The impact of these histopathological growth patterns on relapse characteristics is unknown. We therefore analyzed paired biopsies obtained at initial diagnosis and relapse from 33 NLPHL patients who had received first-line treatment within German Hodgkin Study Group (GHSG) trial protocols, and from a second cohort of 41 relapsed NLPHL patients who had been treated outside GHSG studies. Among the 33 GHSG patients, 21 patients presented with a typical growth pattern at initial diagnosis, whereas 12 patients had a variant histology. The histopathological growth patterns at initial diagnosis and at relapse were consistent in 67% of cases. A variant histology at initial diagnosis was associated with a shorter median time to lymphoma recurrence (2.8 vs 5.2 years; P = .0219). A similar tendency towards a shorter median time to lymphoma recurrence was observed for patients presenting with a variant histology at relapse, irrespective of the growth pattern at initial diagnosis. Results obtained from the 41 NLPHL patients who had been treated outside GHSG studies were comparable (median time to lymphoma recurrence for variant histology vs typical growth pattern at initial diagnosis: 1.5 vs 7.0 years). In conclusion, the histopathological growth pattern remains consistent at relapse in the majority of NLPHL cases, and has major impact on the time of relapse. |
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