Micronucleus induction by diuron in mouse bone marrow |
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| Affiliation: | 1. School of Biology, Food and Environment, Hefei University, Hefei, 230601, PR China;2. Anhui Province Key Laboratory of Environmental Toxicology and Pollution Control Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031, PR China;3. Institute of Physical Science and Information Technology, Anhui University, Hefei, 230601, PR China;1. Department of Cell Biology, University of Seville, Avda. Reina Mercedes 6, 41012 Seville, Spain,;2. Department of Pharmacology, Faculty of Pharmacy, University of Seville, c/Professor García González, No. 2, 41012, Seville, Spain;3. Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, S-17121, Stockholm, Sweden;1. Cytogenetics and Molecular Toxicological Laboratory, Section of Genetics, Department of Zoology, Aligarh Muslim University, Aligarh 202002, Uttar Pradesh, India;2. Molecular Cancer Genetics & Translational Research Lab, Section of Genetics, Department of Zoology, Aligarh Muslim University, Aligarh 202002, Uttar Pradesh, India;1. College of Pharmacy, Pharmacology and Toxicology Department, King Saud University, Riyadh, Saudi Arabia;2. College of Pharmacy, Undergraduate Student, Ain Shams University, Cairo, Egypt;3. College of Pharmacy, Pharmacology and Toxicology Department, Al-Azhar University, Cairo, Egypt;1. Division of Pathology, National Institute of Health Sciences, Tokyo 158-8501, Japan;2. Biological Safety Research Center, National Institute of Health Sciences, Tokyo 158-8501, Japan |
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| Abstract: | Diuron, a widely used substituted urea herbicide, induced the formation of micronuclei in bone marrow cells of Swiss mice. A single i.p. dose of 340 mg/kg b.w. diuron which is maximum tolerated dose (MTD) increased significantly the number of micronuclei at 30 h and 48 h time period. The dose of 170 mg/kg b.w. also induced the micronuclei formation in the above time period. However, a dose of 85 mg/kg b.w. was ineffective at the time periods studied. No induction of micronuclei was observed at 72 h time period after all the doses of diuron studied as compared to the solvent control. The diuron-induced frequency of micronucleated erythrocytes was independent of the sex of the test animals. |
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