瘦素、脂代谢与胆固醇结石形成的相关性

目的通过对胆固醇结石患者血清瘦素及血脂成分浓度的测定,旨在探讨瘦素(LP)在胆固醇结石形成中的作用。方法收集兰州医学院第二附属医院普外科胆结石住院患者,确定22例作为实验组(胆石组),其中男10例,女12例。术后通过肉眼观察和化学检测证实为胆固醇结石。患者术前进行各项检查排除心、肝、肾等器官病变,且无高血压、糖尿病、肝炎等慢性病变,不伴或伴胆囊炎但非急性发作者。另外,随机抽取本院经体检及生化全项检查无血脂增高及其他明显病变的健康人群16例,其中男8例,女8例,作为对照组。用生化法检测胆固醇结石组患者及对照组血清总胆汁酸(TBA)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、载脂蛋白的含量;并测身高、体重、腰围,计算体重指数(BMI)、体表面积;用放免法测血清瘦素值。结果胆石组和对照组血脂成分差异具有显著意义。HDL:胆石组为(1.21±0.27)mmol/L,对照组为(1.5±0.3)mmol/L,结石组比对照组低,差异具有显著性意义(t=2.21,P<0.05);血清胆固醇:胆石组为(4.6±0.7)mmol/L,对照组为(4.0±1.0)mmol/L,差异具有显著性意义(t=2.40,P<0.05);载脂蛋白A1(apo-a1):胆石组为(1.28±0.28)g/L,对照组为(1.53±0.25)g/L,差异也具有显著性意义(t=2.56,P<0.05)。胆石组血清瘦素含

Relationship between serum leptin and lipids in patients with cholesterol gallstone

Aim To investigate relationship between leptin and serum lipids in cholesterol gallstone patients by measuring serum leptin and lipids.Methods Twenty-two patients(10 males and 12 females) in the experimental group were diagnosed as gallstone by ultrasound without hyperten sion,diabetes,hepatitis and other acute and chronic diseases.The patients complicated with acute cholecystitis calculus of intrahepatic duct and obstruction of biliary tract were excluded from this study.Meantime,16 healthy persons(8 males and 8 females) without hyperlipidemia and other obvious disease changes were chosen as the control group by physical and biochemical examination.The levels of TBA,TC,TG,HDL,LDL and content of apolipoprotein in both groups were measured by routine biochemistry.In addition,the level of leptin was also measured by radioimmunoassay.Meantime, body height, mass and waistline were measured.Results HDL of cholesterol gallstone group (1.21± 0.27) mmol/L was lower than that in control group(1.5± 0.3) mmol/L (t=2.21,P< 0.05).Significantly higher level of TC were found in the gallstone group compared with the control group(4.6± 0.7) mmol/L vs (4.0± 1.0) mmol/L,t=2.40,P< 0.05].The levels of serum high density lipoprotein and apolipoproteinAl in cholesterol gallstone group was significantly lower than that in the control group(1.28± 0.28) g/L vs (1.53± 0.25) g/L,t=2.56,P< 0.05].The serum leptin in cholesterol gallstone group was higher than that in control group(19± 16) μ g/L vs (9± 4) μ g/L,t=3.09,P< 0.01].Conclusion The leptin level is closely related to formation of cholesterol gallstone.