| 鳞癌相关抗原在鳞癌及相关良性疾病中的临床意义 |
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| 引用本文： | 周扬,高静,贾兴旺,向荣,田亚平. 鳞癌相关抗原在鳞癌及相关良性疾病中的临床意义[J]. 标记免疫分析与临床, 2010, 17(3): 137-140. DOI: 10.3969/j.issn.1006-1703.2010.03.001 |
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| 作者姓名： | 周扬 高静 贾兴旺 向荣 田亚平 |
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| 作者单位： | 解放军总医院生化科,北京,100853;南开大学医学院,天津,300071;解放军总医院生化科,北京,100853;南开大学医学院,天津,300071 |
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| 摘 要： | 探讨鳞状细胞癌相关抗原（squamous cell carcinoma-related antigen,SCC-Ag）在鳞状细胞癌（鳞癌）和良性疾病中的诊断和临床监测意义及其与病理分级、临床分期的关系。采用微粒子酶免疫分析技术对167例鳞癌患者、96例相关良性疾病患者和96名健康对照者进行了血清SCC-Ag水平的检测,对各组SCC-Ag的表达水平和阳性率进行统计学分析。结果表明,鳞癌患者血清SCC-Ag表达水平显著高于健康对照者和良性疾病患者（P〈0.01）,SCC-Ag对鳞癌的诊断灵敏度为61.1%、特异性为91.7%,其ROC曲线下面积为0.825,表示SCC-Ag对鳞癌的诊断较为准确,可作为重要的诊断依据;宫颈鳞癌SCC-Ag表达水平和阳性率与临床分期呈正相关,但与病理分化不相关;良性疾病患者和健康对照组的SCC-Ag表达水平分布差异显著（P〈0.05）。血清SCC-Ag表达水平可作为肺鳞癌、宫颈鳞癌以及食管鳞癌诊断的特异性指标,在鳞癌及良性疾病的鉴别诊断中有很大的临床意义。
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| 关 键 词： | 鳞状细胞癌相关抗原 鳞癌 良性疾病 辅助诊断 |
The Clinical Performance of SCC-Ag in Squamous Cell Carcinoma and Related Benign Diseases |
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| ZHOU Yang,GAO Jing,JIA Xing-wang,XIANG Rong,TIAN Ya-ping. The Clinical Performance of SCC-Ag in Squamous Cell Carcinoma and Related Benign Diseases[J]. Labeled Immunoassays and Clinical Medicine, 2010, 17(3): 137-140. DOI: 10.3969/j.issn.1006-1703.2010.03.001 |
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| Authors: | ZHOU Yang GAO Jing JIA Xing-wang XIANG Rong TIAN Ya-ping |
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| Affiliation: | ZHOU Yang,GAO Jing,JIA Xing-wang,XIANG Rong,TIAN Ya-ping(Department of Clinical Biochemistry,PLA General Hospital,Beijing 100853,China) |
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| Abstract: | To investigate the clinical performance of squamous cell carcinoma antigen(SCC-Ag) as a tumor marker in the auxiliary diagnosis and clinical monitor of squamous cell carcinoma and related benign diseases,and to explore the relationship between serum SCC-Ag level and the clinical stage,pathological grade of cervical squamous cell carcinoma,the serum level of SCC-Ag in 167 patients with squamous cell carcinoma,96 patients with related benign diseases and 96 healthy individuals were measured by Microparticle E... |
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| Keywords: | Squamous cell carcinoma antigen Squamous cell carcinoma Inflammation Auxiliary diagnosis |
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